Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Role and treatment of early maladaptive schemas in Vietnam veterans with PTSD [PDF]
, 2010 The role of early maladaptive schemas in understanding and treating post-traumatic stress disorder (PTSD) was investigated. The first study examined the role of perceived adverse parenting and early maladaptive schemas in the development of PTSD in ...
Cockram, D.M., Lee, C.W., Drummond, P.D.
core
The effectiveness of emotional schema therapy on emotional schemas of female victims of child abuse and neglect [PDF]
, 2014 Introduction: Development of emotional schemas is regarded as one of the long term effects of child abuse and neglect. Therefore, the present study aimed to investigate the effect of Emotional Schema Therapy on emotional schemas of female victims of ...
Izadikhah, Zahra +3 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2023 Research into the cognitive behavioural treatment of eating disorders (EDs) has largely focused on the content of cognitions and their relation to ED pathology.
Stavropoulos, A, Brockman, R
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
International Validation of the Young Schema Questionnaire Revised Plus (YSQ-R Plus): Proposal of a Research Protocol with an Italian Contribution [PDF]
, 2023 openLa Schema Therapy è un innovativo approccio psicoterapeutico interdisciplinare metodicamente sviluppato per il trattamento di una vasta gamma di disturbi psicologici. Il presente elaborato, con riferimento allo stato della letteratura, si propone di
VALENTE, ANGELO
core
bowtie-json-schema/bowtie: v0.64.0
, 2022 What's Changed [pre-commit.ci] pre-commit autoupdate by @pre-commit-ci in https://github.com/bowtie-json-schema/bowtie/pull/126 Full Changelog: https://github.com/bowtie-json-schema/bowtie/compare/v0.63.6...v0.64.
Julian Berman +4 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source