Results 51 to 60 of about 198,870 (287)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Positive Psychology Couple Schema Therapy: A new model of couple therapy focusing on reigniting couple attraction via schema therapy and positive psychology

, 2020
Introduction: There is growing evidence indicating schema modes influences emotional and behavioural response in couple interaction which affects relationship satisfaction. Thus, identifying dominant schema modes is important for effective couple therapy.
Huey Jing Renee TAN, Edward Weng Lok CHAN,
core  

The Comparison of the Effectiveness of Emotional Schema Therapy and Mindfulness-Based Cognitive Therapy on Cognitive Emotion Regulation, Intolerance of Uncertainty, and Cognitive Flexibility in Patients with Generalized Anxiety Disorder [PDF]

پژوهش‌های کاربردی روانشناختی
The objective was to compare the effectiveness of emotional schema therapy and cognitive therapy based on mindfulness on cognitive regulation of emotion, intolerance of uncertainty, and cognitive flexibility.
Kobra Ghanizadeh Balderloo, Naimeh Moheb, Marziyeh Alivandi Vafa, Masoumeh Azemoudeh   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The effectiveness of emotional schema therapy on emotional schemas of female victims of child abuse and neglect [PDF]

, 2014
Introduction: Development of emotional schemas is regarded as one of the long term effects of child abuse and neglect. Therefore, the present study aimed to investigate the effect of Emotional Schema Therapy on emotional schemas of female victims of ...
Izadikhah, Zahra, Daneshmandi, Saeedeh, Mehrabi, Hossein, Kazemi, Hamid   +3 more
core  

The Effect of Schema Therapy-Based Group Counseling on Reducing the Psychological Distress Adolescents of Divorce [PDF]

پژوهش‌های کاربردی روانشناختی
The purpose of the research was to investigate the effectiveness of schema therapy, which is founded on group counseling, in alleviating the psychological distress experienced by adolescents who have experienced divorce.
Farzaneh Monjezi, Esmail Asadpour, Mohsen Rasouli, Kianoosh Zahrakar   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comparative Efficacy Analysis of Nature-Adventure Therapy Based Schema Therapy (N-ABST) and classic Schema Therapy (ST)

, 2023
At Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, a complex Nature-, and Adventure Therapy integrated schema therapeutic program (N-ABST) will be launched for the first time in 2022.
Kenézlői Eszter MD
core   +1 more source