Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. [PDF]
, 2014 The aim of the present study was to examine the efficacy of tumor-targeting Salmonella typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) therapy on VEGF-positive human pancreatic cancer.
Bouvet, Michael +17 more
core +2 more sources
مراقبت پرستاری و مامایی ابن سینا, 2020 Introduction: Due to the prevalence of obsessive-compulsive symptoms (OCS), and also delayed diagnosis and pharmacological treatment and the possibility of their recurrence after cognitive-behavioral therapies, it is necessary to plan some measures to ...
Masood Ahovan +2 more
doaj
Intimate Partner Violence from Schema Therapy Perspective
Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2019 Schema Therapy developed by Jeffrey Young is a psychotherapy method used in the treatment of many psychiatric disorders, particularly personality disorders.
Ayse Gokcen Gundogmus +2 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The effectiveness of cognitive behavioral therapy and schema therapy on happiness and mental health of nursing students [PDF]
, 2016 Background and aims: Cognitive behavioral therapy and schema therapy are known as two common methods to promote happiness and mental health. This research aimed to investigate the effectiveness cognitive behavioral therapy and schema therapy in improving
Ashoori, Jamal. +4 more
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Comparing the effectiveness of meta-cognitive therapy and schema therapy on decrease symptoms of anxiety and depression in nursing and midwifery students [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2015 Background: Meta-cognitive therapy and schema therapy are two important methods in treatment of mental disorders special in treatment of anxiety and depression. This study aimed to compare the effectiveness of meta-cognitive therapy and schema therapy on
Ashoori J
doaj
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]
, 2019 Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A. +10 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source