Results 51 to 60 of about 274,555 (304)

Increasing access to CBT for psychosis patients: a feasibility, randomised controlled trial evaluating brief, targeted CBT for distressing voices delivered by assistant psychologists (GiVE2) [PDF]

, 2020
Background: The National Institute for Health and Care Excellence (NICE) recommends that Cognitive Behaviour Therapy for psychosis (CBTp) is offered to all patients with a psychosis diagnosis. However, only a minority of psychosis patients in England and
Arnold, Kate, Berry, Clio, Berry, Katherine, Bremner, Stephen, Cameron, Ben, Cavanagh, Kate, Fowler, David, Gage, Heather, Greenwood, Kathryn, Hayward, Mark, Hazell, Cassie, Jones, Anna-Marie, Robertson, Sam, Strauss, Clara   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Metacognition as a predictor of improvements in personality disorders [PDF]

, 2019
Personality Disorders (PDs) are particularly hard to treat and treatment drop-out rates are high. Several authors have agreed that psychotherapy is more successful when it focuses on the core of personality pathology.
Antonino Carcione, Antonio Semerari, Donatella Fiore, Elena Bilotta, Giovanni Pellecchia, Giuseppe Nicolò, Ilaria Riccardi, Laura Conti, Livia Colle, Livia Colle, Luigi Leone, Michele Procacci, Roberto Pedone, Roberto Pedone   +13 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Comparison of the Effectiveness of Emotional Schema Therapy and Mindfulness-Based Cognitive Therapy on Cognitive Emotion Regulation, Intolerance of Uncertainty, and Cognitive Flexibility in Patients with Generalized Anxiety Disorder [PDF]

پژوهش‌های کاربردی روانشناختی
The objective was to compare the effectiveness of emotional schema therapy and cognitive therapy based on mindfulness on cognitive regulation of emotion, intolerance of uncertainty, and cognitive flexibility.
Kobra Ghanizadeh Balderloo, Naimeh Moheb, Marziyeh Alivandi Vafa, Masoumeh Azemoudeh   +3 more
doaj   +1 more source

Assessment and treatment of distorted schemas in sexual offenders [PDF]

, 2013
The aim of this review is to examine the literature related to the assessment and treatment of sex offenders’ distorted schemas. Where appropriate, the review draws upon current insights from the field of social cognition to aid in the critical ...
Anthony R. Beech, Babchishin K. M., Barnes-Holmes D., Beckett R. C., Beech A. R., Bennett A. H., Check J., De Houwer J., Fiske S. T., Gawronski B., Goddard H. L., Harkins L., Hermann C. A., Hermann C. A., Jones J., Kahneman D., Louise Dixon, Mamone N., Mann R. E., Mann R. E., McGinn L. K., McGrath R. J., Moran Y., Nichols I., Pervan M., Ross M. Bartels, Salter R. L., Scully B., Smid R. J., Steffens E., Thornton J., Thornton R. E., Ward S.   +32 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

More Than Memories? Schema Transference from Media Characters to Real People [PDF]

, 2011
This study focused on whether personality traits and evaluations of television personalities are used to make inferences about new Social interaction partners. It tested the hypothesis that priming schemas of television personalities will bias inferences
Ray, Hilary
core   +2 more sources

Shadows along the spiritual pathway [PDF]

, 2015
Contemporary spirituality discourses tend to assume that a canopy of light and love overarches all spiritual pathways. Unfortunately, the dark side of humanity cannot be spirited away so easily, and aberrations of personal spiritual development ...
Humphrey, Caroline
core   +1 more source