Results 231 to 240 of about 4,462,665 (297)

Chiral spin-crossover complexes based on an enantiopure Schiff base ligand with three chiral carbon centers.

Dalton Trans
Regueiro A, García-López V, Forment-Aliaga A, Clemente-León M.   +3 more
europepmc   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan, Lixia Huang, Yingyue Xu, Ya Huang, Xiaojun Yang   +4 more
wiley   +1 more source

Synthesis, Cytotoxic Activity, mRNA Expression, Total Oxidant and Antioxidant Status, and Molecular Modeling Studies of Novel Schiff Base–Thiosemicarbazone Hybrids

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In this study, new Schiff base‐derived compounds were synthesized, and their structures were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and HRMS analyses. The cytotoxic effects of the compounds on a prostate cancer cell line (PC3) were investigated, and it was determined that the compounds NZ10, NZ9, NZ7, and NZ4, in particular, exhibited potent anticancer ...
Anber M Anber, Mehmet Özbay, İlhan Özer İlhan, Hüseyin Kekeçmuhammed, Rıfat Emin Bora, Emin Saripinar, Yalçın Erzurumlu, Muhammed Tilahun Muhammed, Sadeq K. Alhag, Lamya Ahmed Alkeridis, Senem Akkoc   +10 more
wiley   +1 more source

Injectable Zn2+‐Alginate Hydrogel Delivering NT3 for Anti‐Inflammatory and Neuroregenerative Therapy in Spinal Cord Injury

Small Structures, Volume 7, Issue 11, November 2026.
An injectable Zn2+‐alginate hydrogel functionalized with His‐tagged NT3 is developed for spinal cord injury repair. The hydrogel modulates microglial polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotype via TNF‐α–NF‐κB pathway inhibition, while sustained NT3 delivery promotes axonal regeneration, synaptogenesis, and remyelination ...
Chao Wang, Quancheng Cheng, Jingyi Yang, Man Li, Yifan Yao, Ziyuan Wang, Xuan Fang, Chunhua Chen, Chuanda Zhu, Weiguang Zhang   +9 more
wiley   +1 more source

Covalent Organic Frameworks in Smart Food Packaging: Advances, Challenges, and Future Prospects

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT Food preservation challenges have positioned packaging as a rapidly evolving, innovation‐driven field, with smart packaging offering transformative solutions. Among advanced materials, covalent organic frameworks (COFs) have attracted growing attention due to their permanent porosity, structural tunability, high surface area, and chemical ...
Sara Esteghlal, Hossein Daneshgar, Navid Rabiee, Mohammadreza Khalesi   +3 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

HvPHO1 Controls a Glucose 1‐Phosphate–SnRK1 Signalling Module That Coordinates Starch Accumulation in Barley Endosperm

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5891-5910, November 2026.
ABSTRACT Developing barley grains must balance the use of imported sucrose between soluble sugars and storage starch, but how this balance is controlled remains unclear. Here we show that loss of the plastidial α‐glucan phosphorylase HvPHO1 causes starch and soluble sugars to accumulate concurrently in barley grains.
Yulong Li, Yujia Chen, Jing Liu, Ping Yang, Guangqi Gao, Carlos Guzmán, Qiang Xu, Yazhou Zhang, Yanlin Liu, Pengfei Qi, Mei Deng, Shoufen Dai, Jian Ma, Guoyue Chen, Jirui Wang, Youliang Zheng, Yuming Wei, Qiantao Jiang   +17 more
wiley   +1 more source

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source