Results 41 to 50 of about 27,347 (176)

Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children [PDF]

, 2012
BACKGROUND: Praziquantel is the drug of choice in preventive chemotherapy targeting schistosomiasis. Increasing large-scale administration of praziquantel requires monitoring of drug efficacy to detect early signs of development of resistance.
Lohourignon Laurent K, Krauth, Stefanie J., Utzinger, Jürg, Coulibaly, Jean T., Jean T Coulibaly, Katarina Stete, Stefanie Knopp, Utzinger Jürg, N’Goran, Eliézer K., Stete, Katarina, Winfried V Kern, Lohourignon, Laurent K., Ivan Müller, Jürg Utzinger, Hattendorf Jan, Stete Katarina, Stefanie J Krauth, Coulibaly Jean T, Krauth Stefanie J, Müller Ivan, Laurent K Lohourignon, Müller, Ivan, N’Goran Eliézer K, Kern Winfried V, Hattendorf, Jan, N'Goran, Eliézer K., Knopp, Stefanie, Kern, Winfried V., Knopp Stefanie, Eliézer K N’Goran, Jan Hattendorf   +30 more
core   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni [PDF]

, 2015
BACKGROUND: Drug discovery for the neglected tropical disease schistosomiasis has a high priority. Anticancer drugs, especially protein kinase inhibitors, might serve as a starting point for drug discovery owing to the importance of protein kinases in ...
Cowan, Noemi, Jennifer Keiser, Keiser, Jennifer, Noemi Cowan   +3 more
core   +1 more source

Hepatitis G Virus Infection in Patients with Hepatitis C

Journal of High Institute of Public Health, 2010
Hepatitis G virus (HGV) infection is a worldwide health problem causing acute and chronic non A- E hepatitis. Because HGV and hepatitis C virus (HCV) share same modes of transmission, co-infection with the two viruses is not uncommon especially among ...
Heba S. Selim, Mohamed A.El Barrawy, Osama N. Mohamed, Marwa S. Gamal El Din   +3 more
doaj   +1 more source

Urinary Schistosomiasis Detected by Chance in India: A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2020
Schistosomiasis is a parasitic trematode that is less commonly seen in India. The clinical manifestations range from acute, sub acute and chronic phases. A granulomatous type of lesion formed by Schistosoma hematobium in the lower urinary tract.
Flora D. Lobo , Anusha S. Bhatt, Pooja Rao, G. G. Laxman Prabhu   +3 more
doaj  

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial [PDF]

, 2012
BACKGROUND: Schistosomiasis and opisthorchiasis are of public health importance in Southeast Asia. Praziquantel (PZQ) is the drug of choice for morbidity control but few dose comparisons have been made.
Youthanavanh Vonghachack (148917), Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong (148913), Jennifer Keiser, Utzinger, Jürg, Tanner, M., Odermatt Peter, Leonore Lovis (148903), Utzinger Jürg, Youthanavanh Vonghachack, Peter Odermatt, Hatz, Christoph, Vounatsou Penelope, Vounatsou, P., Phonepasong Ayé Soukhathammavong, Jennifer Keiser (39606), Phongluxa, Khampheng, Sripa, Banchob, Soukhathammavong, Phonepasong Ayé, Ayé Soukhathammavong Phonepasong, Soukhathammavong, P. A., Vonghachack, Youthanavanh, Utzinger, J., Jürg Utzinger (39609), Tanner Marcel, Tippi K Mak, Christoph Hatz (35423), Penelope Vounatsou (49253), Phongluxa Khampheng, Akkhavong, Kongsap, Mak, T. K., Akkhavong Kongsap, Kongsap Akkhavong (148931), Tippi K. Mak (148907), Marcel Tanner (33894), Penelope Vounatsou, Hatz, C., Marcel Tanner, Mak Tippi K., Lovis, L., Mak, Tippi K, Jürg Utzinger, Kongsap Akkhavong, Leonore Lovis, Tanner, Marcel, Vonghachack Youthanavanh, Keiser Jennifer, Odermatt, P., Keiser, J., Odermatt, Peter, Akkhavong, K., Peter Odermatt (148926), Keiser, Jennifer, Hatz Christoph, Lovis, Leonore, Vonghachack, Y., Khampheng Phongluxa (148910), Lovis Leonore, Vounatsou, Penelope, Christoph Hatz, Phongluxa, K.   +60 more
core   +2 more sources

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays [PDF]

, 2015
Schistosomiasis is responsible for a tremendous public health burden, yet only a single drug, praziquantel, is available. New antischistosomal treatments should therefore be developed. The accuracy, speed and objectivity of in vitro drug screening depend
Gordana Panic, Jennifer Keiser, Flores, Dayana, Keiser, Jennifer, Ingram-Sieber, Katrin, Dayana Flores, Katrin Ingram-Sieber, Panic, Gordana   +7 more
core   +1 more source