Results 11 to 20 of about 98,465 (295)

Extracellular Vesicles From Schistosoma mansoni Adult Worms Stimulate IL-10 Release by B Cells. [PDF]

Parasite Immunol
ABSTRACT Schistosome parasites are known to modulate host immune responses, which is achieved in part through the release of excretory/secretory (ES) products, including extracellular vesicles (EVs). During chronic schistosomiasis, increased regulatory responses are found, which include enhanced IL‐10 production by B (Breg) cells.
Kuipers ME, Ozir-Fazalalikhan A, Haeberlein S, Driessen NN, de Korne CM, Mes L, Hensbergen PJ, Nolte-'t Hoen ENM, Hokke CH, Smits HH.   +9 more
europepmc   +2 more sources

Pharmacological Inhibition of c-Jun N-Terminal Kinase Activity Exacerbates Liver Damage in Schistosoma mansoni Infected Mice. [PDF]

Liver Int
ABSTRACT Background and Aims Schistosomiasis is a neglected tropical disease affecting more than 250 million people worldwide. Eggs of the parasitic helminth S. mansoni cause major morbidity in the liver, spleen and intestine. Of note, egg‐released soluble antigens (SEA) induce the transcription factor c‐Jun in hepatocytes, promoting hepatocellular ...
Stettler F, Knedla L, Hagen M, von Bülow V, Müller H, Tschuschner A, Zahner D, Haeberlein S, Moescheid MF, Windhorst A, Burg-Roderfeld M, Glebe D, Moreira BP, Lesieur C, Schmid A, Falcone FH, Grevelding CG, Roeb E, Roderfeld M.   +18 more
europepmc   +2 more sources

Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni

Science, 2020
Schistosome biology illuminated Schistosomiasis is caused by a parasitic flatworm about which little is known. Therefore, options to combat human disease caused by schistosome infection are limited.
Jipeng Wang, Carlos Paz, G. Padalino, Avril Coghlan, Zhigang Lu, I. Grădinaru, Julie N. R. Collins, M. Berriman, K. Hoffmann, James J. Collins   +9 more
semanticscholar   +1 more source

Effects of Water Source, Sanitation and Hygiene on the Prevalence of Schistosoma mansoni among School Age Children in Jawe District, Northwest Ethiopia

Iranian Journal of Parasitology, 2020
Background: Intestinal schistosomiasis is a disease caused by infection with one of the blood flukes called Schistosoma mansoni. The distribution of Schistosoma mansoni infection is high in Sub-Saharan Africa due to water source, sanitation and hygiene ...
Tadesse HAILU, Wondemagegn MULU, Bayeh ABERA   +2 more
doaj   +1 more source

Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018

Emerging Infectious Diseases, 2020
In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected ...
S. Catalano, E. Léger, C. Fall, A. Borlase, S. Diop, Duncan J. Berger, B. Webster, B. Faye, Nicolas D. Diouf, D. Rollinson, Mariama Sène, K. Bâ, J. Webster   +12 more
semanticscholar   +1 more source

Chemosterilization of Schistosoma mansoni [PDF]

Nature, 1968
THE range of chemical agents which can produce sterility in experimental male rodents is gradually increasing. (For recent surveys, see Jackson1,2.) The list includes nitroaromatic compounds, for example, nitrofuranes, nitrothiazoles and nitropyrroles, besides a variety of compounds of the alkylating category.
Harold Jackson, P. Davies, Marion Bock
openaire   +3 more sources

Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections

Parasite immunology (Print), 2020
Schistosomiasis is the most important helminth disease in the world from a public health perspective. S mansoni and S japonicum account for the majority of global intestinal schistosomiasis cases, and the pathogenesis is widely assumed to be ...
Felix Llanwarne, H. Helmby
semanticscholar   +1 more source

Identification of Schistosoma mansoni microRNAs [PDF]

BMC Genomics, 2011
Abstract Background MicroRNAs (miRNAs) constitute a class of single-stranded RNAs which play a crucial role in regulating development and controlling gene expression by targeting mRNAs and triggering either translation repression or messenger RNA (mRNA) degradation. miRNAs are widespread in eukaryotes and to date over
Gustavo C. Cerqueira, Gustavo C. Cerqueira, Andrew R. Dalby, Philip T. LoVerde, Jonathan M. Lee, Appolinaire Djikeng, Appolinaire Djikeng, Adhemar Zerlotini, Adhemar Zerlotini, Rosiane A. Silva-Pereira, Najib M. El-Sayed, Guilherme Oliveira, Mariana Simoes, Mariana Simoes   +13 more
openaire   +6 more sources

Characteristics of persistent hotspots of Schistosoma mansoni in western Côte d’Ivoire

Parasites & Vectors, 2020
Preventive chemotherapy with praziquantel is the cornerstone of schistosomiasis control. However, in some social-ecological settings, the prevalence and/or intensity of Schistosoma infection does not lower meaningfully despite multiple rounds of ...
Rufin K Assaré, R. N. N’Tamon, L. Bellai, Judicaelle A. Koffi, T. Mathieu, M. Ouattara, Eveline Hürlimann, J. Coulibaly, S. Diabaté, E. N'Goran, J. Utzinger   +10 more
semanticscholar   +1 more source

Schistosoma mansoni associated glomerulopathy [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1999
(1)Institute of Tropical Medicine, Sao Paulo, SP, Brasil. (2)Division of Nephrology, “Hospital das Clinicas”, University of S. Paulo, Medical School, S. Paulo, SP, Brasil. (3)Sao Paulo Federal University Medical School, Dept. of Microbiology, Immunology, and Parasitology, S. Paulo, SP, Brazil. Correspondence to: Dr. Thales De Brito, Av. Dr.
BRITO, T. DE, NUSSENZVEIG, I., CARNEIRO, Célia R.W., SILVA, Ana Maria G.   +3 more
openaire   +5 more sources