Results 31 to 40 of about 44,135 (156)

Schistosome-induced portacaval haemodynamic changes in Rattus rattus are associated with translocation of adult worms to the lungs [PDF]

, 1998
The presence of naturally portacaval shunts has been investigated in the vasculature of normal and Schistosoma mansoni-infected Rattus rattus. Using the technique of injecting Polystyrene microspheres in the superior mesenteric vein, we demonstrated that
Coulson, P.S., Imbert-Establet, D., Mone, H., Wilson, R.A.   +3 more
core   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Point of Care Diagnosis of Multiple Schistosome Parasites: Species-specific DNA Detection in Urine by Loop-mediated Isothermal Amplification (LAMP) [PDF]

, 2017
Schistosomes are easily transmitted and high chance of repeat infection, so if control strategies based on targeted mass drug administration (MDA) are to succeed it is essential to have a test that is sensitive, accurate and simple to use.
Anyan, William K., Bosompem, Kwabena M., Lodh, Nilanjan, Mikita, Kei, Otchere, Joseph, Quartey, Joseph K., Shiff, Clive J.   +6 more
core   +2 more sources

Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase

Pest Management Science, EarlyView.
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier, David M Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Uwe Döller, Tyler Fahrenhorst‐Jones, Jörg Freigang, Elmar Gatzweiler, Claudia Hartfiel, Caroline Hilmi, Yoann Huet, Bernd Laber, Gudrun Lange, Stephanie Lee, Virginie Lempereur, Marc Mosrin, Thomas Müller, China M Payne, Olaf Peters, Luka Posa, Shaun Rees, Anna M Reingruber, Jullien Rey, Jörg Tiebes, Karen Tilmant, Jens Frackenpohl   +26 more
wiley   +1 more source

The schistosome egg: development and secretions [PDF]

, 2001
We have investigated the development of the schistosome egg and its secretions in order to understand how it migrates through gut tissues and also initiates pathology in the liver.
Ashton, P.D., Harrop, R., Shah, B., Wilson, R.A.   +3 more
core   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Fucosyltransferases in Schistosoma mansoni development [PDF]

Glycobiology, 2001
Glycoconjugate-bound fucose, abundant in the parasite Schistosoma mansoni, has been found in the form of Fucalpha1,3GlcNAc, Fucalpha1,2Fuc, Fucalpha1,6GlcNAc, and perhaps Fucalpha1,4GlcNAc linkages. Here we quantify fucosyltransferase activities in three developmental stages of S. mansoni.
Mette Strand, Yoshitaka Ichikawa, J. T. August, Ronald L. Schnaar, Ernesto T. A. Marques, Gerald W. Hart   +5 more
openaire   +3 more sources

Photodynamic therapy of cancer‐associated infections

Photochemistry and Photobiology, EarlyView.
Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Giulia Kassab, Juan Chen, Gang Zheng
wiley   +1 more source

The Schistosoma mansoni transcriptome: An update [PDF]

Experimental Parasitology, 2007
Large scale EST sequencing projects have been carried out for Schistosoma mansoni and Schistosoma japonicum. This update will briefly review the most recent accomplishments in the area and discuss the use of EST data for the purposes of gene discovery, gene model development, genome annotation and SNP analysis. In addition, the use of ESTs for studying
openaire   +3 more sources

Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes [PDF]

, 2015
The last decade has seen an expansion of national schistosomiasis control programmes in Africa based on large-scale preventative chemotherapy. In many areas this has resulted in considerable reductions in infection and morbidity levels in treated ...
A Garba, AD Barbour, AD Barbour, AJ Fulford, AJ Fulford, Alan Fenwick, Amadou Garba, AP Plaisier, AP Plaisier, ARC Harris, AW Cheever, B Bolker, B Payet, BL Webster, BL Webster, BL Webster, BR Kirkwood, CH King, CH King, D Engels, D Gurarie, DL Smith, E Michael, E Miguel, EK N'Goran, Elisa Bosqué-Oliva, Fiona M. Fleming, G Webbe, GA Macdonald, GE Box, GF Medley, H Laamrani, H Tanaka, Hairston NG, HC Turner, HC Turner, HP Duerr, I Nåsell, I Nåsell, J Utzinger, J Utzinger, James Mwansa, JH Ouma, Joanne P. Webster, JP Webster, JW Rudge, JW Rudge, L Van Etten, LA Tchuem-Tchuenté, LA Tchuem-Tchuenté, Lynsey Blair, M Booth, M Parker, M Tanner, M-G Basáñez, M-G Basáñez, Maria-Gloria Basáñez, ME Woolhouse, Michael D. French, ML Steinauer, Moussa Sacko, MS Chan, MS Chan, MS Chan, N Katz, Narcis B. Kabatereine, NB Kabatereine, NG Hairston, RM Anderson, RM Anderson, RM Anderson, RM Anderson, RM May, Seydou Toure, SJ de Vlas, SM Blower, Team" RDC, Thomas S. Churcher, Ursuline Nyandindi, WHO   +79 more
core   +3 more sources