Results 1 to 10 of about 46,909 (203)

miR-181a regulates the host immune response against Schistosoma japonicum infection through the TLR4 receptor pathway

Parasites & Vectors, 2021
Background Schistosomiasis japonica is a serious zoonotic parasitic disease. Preliminary studies have shown that the expression of microRNA-181a (miR-181a) in the liver, lung and spleen tissues of susceptible host BALB/c mice and resistant host reed vole
Yixiao Tang, Yuanxi Shen, Yang Hong, Zuhang Zhang, Qi Zhai, Zhiqiang Fu, Hao Li, Ke Lu, Jiaojiao Lin   +8 more
doaj   +1 more source

Sja-Let-7 Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in a Mouse Model via Col1α2

Biology, 2023
Liver fibrosis (LF) is a chronic progressive disease with no definitive treatment. The aim of this study was to assess helminth-derived molecules as potential therapeutic targets to prevent or reverse LF.
Haoran Zhong, Bowen Dong, Danlin Zhu, Hao Li, Ke Lu, Zhiqiang Fu, Jinming Liu, Yamei Jin   +7 more
doaj   +1 more source

Characterisation and preliminary functional analysis of N-acetyltransferase 13 from Schistosoma japonicum

BMC Veterinary Research, 2021
Background N-acetyltransferase 13 (NAT13) is a probable catalytic component of the ARD1A-NARG1 complex possessing alpha (N-terminal) acetyltransferase activity.
Yalan Tang, Kerou Zhou, Qingqing Guo, Cheng Chen, Jing Jia, Qinghong Guo, Ke Lu, Hao Li, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin, Xingang Yu, Yang Hong   +12 more
doaj   +1 more source

Molecular and functional characterization of Schistosoma japonicum annexin A13

Veterinary Research, 2023
Schistosomiasis is a neglected tropical disease that affects humans and animals in tropical and subtropical regions worldwide. Schistosome eggs are responsible for the pathogenesis and transmission of schistosomiasis, thus reducing egg production is ...
Haoran Zhong, Ling Hou, Fanglin Qin, Yuqi Ren, Bowen Dong, Danlin Zhu, Hao Li, Ke Lu, Zhiqiang Fu, Jinming Liu, Shaopeng Gu, Yamei Jin   +11 more
doaj   +1 more source

From Inflammation to Fibrosis: Novel Insights into the Roles of High Mobility Group Protein Box 1 in Schistosome-Induced Liver Damage

Pathogens, 2022
Schistosomiasis is a chronic helminthic disease of both humans and animals and the second most prevalent parasitic disease after malaria. Through a complex migration process, schistosome eggs trapped in the liver can lead to the formation of granulomas ...
Haoran Zhong, Xiang Gui, Ling Hou, Rongxue Lv, Yamei Jin   +4 more
doaj   +1 more source

The Dynamics of Hepatic Fibrosis Related to Schistosomiasis and Its Risk Factors in a Cohort of China

Pathogens, 2021
China has had a long history against schistosomiasis japonica. The most serious prognosis of chronic schistosome infection is hepatic fibrosis, which develops into advanced schistosomiasis if the process is not effectively controlled.
Fei Hu, Shu-Ying Xie, Min Yuan, Yi-Feng Li, Zhao-Jun Li, Zhu-Lu Gao, Wei-Ming Lan, Yue-Ming Liu, Jing Xu, Dan-Dan Lin   +9 more
doaj   +1 more source

Spatio-temporal variations of emerging sites infested with schistosome-transmitting Oncomelania hupensis in Hunan Province, China, 1949–2016

Parasites & Vectors, 2021
Background Constant emerging sites infested with Oncomelania hupensis (O. hupensis) impede the goal realization of eliminating schistosomiasis. The study assessed the spatial and temporal distributions of new Oncomelania snail habitats in Hunan Province ...
Shengming Li, Ying Shi, Weicheng Deng, Guanghui Ren, Hongbin He, Benjiao Hu, Chunlin Li, Na Zhang, Yingyan Zheng, Yingjian Wang, Shurong Dong, Yue Chen, Qingwu Jiang, Yibiao Zhou   +13 more
doaj   +1 more source

Urogenital schistosomiasis in Cabo Delgado, northern Mozambique: baseline findings from the SCORE study

Parasites & Vectors, 2018
Background The results presented here are part of a five-year cluster-randomised intervention trial that was implemented to understand how best to gain and sustain control of schistosomiasis through different preventive chemotherapy strategies.
Anna E. Phillips, Pedro H. Gazzinelli-Guimarães, Herminio O. Aurelio, Neerav Dhanani, Josefo Ferro, Rassul Nala, Arminder Deol, Alan Fenwick   +7 more
doaj   +1 more source

Insights from quantitative and mathematical modelling on the proposed WHO 2030 goal for schistosomiasis [version 1; peer review: 2 approved, 1 approved with reservations]

Gates Open Research, 2019
Schistosomiasis remains one of the neglected tropical diseases (NTDs) impacting millions of people around the world. The World Health Organization (WHO) recently proposed a goal of elimination as a public health problem (EPHP) for schistosomiasis to be ...
NTD Modelling Consortium Schistosomiasis Group
doaj   +1 more source

Insights from quantitative and mathematical modelling on the proposed WHO 2030 goal for schistosomiasis [version 2; peer review: 2 approved, 1 approved with reservations]

Gates Open Research, 2019
Schistosomiasis remains one of the neglected tropical diseases (NTDs) impacting millions of people around the world. The World Health Organization (WHO) recently proposed a goal of elimination as a public health problem (EPHP) for schistosomiasis to be ...
NTD Modelling Consortium Schistosomiasis Group
doaj   +1 more source