Results 81 to 90 of about 93,083 (221)

Characteristics of Intestinal Flora in Patients With Schistosoma japonicum Infection Undergoing Splenectomy

Parasite Immunology, Volume 47, Issue 5, May 2025.
ABSTRACT Schistosomiasis japonica is a parasitic disease that seriously endangers human health. Patients with advanced Schistosoma japonicum infection often suffer from cirrhosis and portal hypertension. Splenectomy has been widely used in the treatment of these patients. Previous studies have confirmed that S. japonicum infection is closely related to
Chen Zhou, Pengpeng Zhang, Yingzi Ming
wiley   +1 more source

Ursolic acid ameliorates CCl4‐induced liver fibrosis through the NOXs/ROS pathway

Journal of Cellular Physiology, Volume 233, Issue 10, Page 6799-6813, October 2018., 2018
UA induces the proliferation of HCs, promotes the apoptosis of HSCs, and prevents the activation of KCs in vivo by reducing the expression of NOXs/ROS in HCs, HSCs, KCs. UA also partly improves phagocytosis of KCs and has no effect on host defense function. Liver fibrosis is a reversible wound‐healing response that occurs after liver injury.
Dakai Gan, Wang Zhang, Chenkai Huang, Jiang Chen, Wenhua He, Anjiang Wang, Bimin Li, Xuan Zhu   +7 more
wiley   +1 more source

An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum

Parasites & Vectors, 2015
Background Schistosomiasis is a chronic parasitic disease that affects approximately 200 million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4+T cell responses to regulate the formation ...
Weiwei Zhang, Jifeng Zhu, Xian Song, Zhipeng Xu, Xue Xue, Xiaojun Chen, Xiaowei Yang, Yong Li, Xiaoxiao Dong, Sha Zhou, Wei Li, Yingying Qian, Feng Liu, Chuan Su   +13 more
doaj   +1 more source

Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicum infection using high-resolution ultrasound imaging

Tropical Medicine and Health, 2018
Background Hepatosplenic lesion formation is one of the typical clinical symptoms of schistosomiasis japonica. Although it is established that circum-oval granuloma formation mediated by T lymphocytes is the key event triggering the formation of hepatic ...
Katsumi Maezawa, Rieko Furushima-Shimogawara, Akio Yasukawa, Nobuo Ohta, Shiro Iwanaga   +4 more
doaj   +1 more source

The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism

Animal Models and Experimental Medicine, Volume 8, Issue 1, Page 114-125, January 2025.
GSDMD‐NTki/wt × Alb‐creki/wt mice showed severe liver damage and hepatocyte vacuolation. The expression of genes involved in the development of liver fibrosis was stronger in the livers of GSDMD‐NTki/wtandAlb‐creki/wt mice. GSDMD‐NT induces fibrosis by mediating lipid metabolism. Abstract Background The emerging incidence of pathogenic liver conditions
Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi   +10 more
wiley   +1 more source

IL‐7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum‐infected mice

Journal of Cellular and Molecular Medicine, Volume 22, Issue 7, Page 3353-3363, July 2018., 2018
Abstract In schistosomiasis japonica and mansoni, parasite eggs trapped in host liver elicit severe liver granulomatous inflammation that subsequently leads to periportal fibrosis, portal hypertension, haemorrhage or even death. Macrophages are critical for granuloma formation and the development of liver fibrosis during schistosomiasis.
Jifeng Zhu, Weiwei Zhang, Lina Zhang, Lei Xu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Ming Xiao, Hui Bai, Feng Liu, Chuan Su   +10 more
wiley   +1 more source

Identification of a linear B-cell epitope on the Schistosoma japonicum saposin protein, SjSAP4: Potential as a component of a multi-epitope diagnostic assay.

PLoS Neglected Tropical Diseases, 2022
BackgroundSchistosoma japonicum is one of three major species of blood flukes causing schistosomiasis, a disease, which continues to be a major public health issue in the Philippines.
Yi Mu, Catherine A Gordon, Remigio M Olveda, Allen G Ross, David U Olveda, Jessica M Marsh, Donald P McManus, Pengfei Cai   +7 more
doaj   +1 more source

Schistosomiasis Chemotherapy, Chemoprevention, and Vaccines: History, Progress, and Priorities

Immunity, Inflammation and Disease, Volume 12, Issue 11, November 2024.
Schistosomiasis is a major human disease of public health importance. The goal is to provide an overview of the history and advancements in schistosomiasis chemotherapy, chemoprevention, and vaccine research. Praziquantel is effective against all species of schistosomiasis, but schistosomiasis prevalence has largely remained unaffected, due to ...
Alaa Oqalaa E. Alibrahim, Walaa A. Elkholy, Mona M. El‐Derbawy, Noha F. Zahran, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +6 more
wiley   +1 more source

TLR3 Modulates the Response of NK Cells against Schistosoma japonicum

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Natural killer (NK) cells are classic innate immune cells that play roles in many types of infectious diseases. NK cells possess many kinds of TLRs that allow them to sense and respond to invading pathogens. Our previous study found that NK cells could modulate the immune response induced by Schistosoma japonicum (S. japonicum) in C57BL/6 mice.
Jiale Qu, Lu Li, Hongyan Xie, Xiaona Zhang, Quan Yang, Huaina Qiu, Yuanfa Feng, Chenxi Jin, Nuo Dong, Jun Huang, Xiaojun Chen   +10 more
wiley   +1 more source

Parasite‐derived microRNA let‐7‐5p detection for metacestodiasis based on rolling circular amplification‐assisted CRISPR/Cas9

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
MicroRNA extraction and RCA‐assisted CRISPR/Cas9 detection. Abstract Metacestodiasis is an infectious disease caused by the larval stage of cestode parasites. This disease poses a serious health hazard to wildlife, livestock, and humans, and it incurs substantial economic losses by impacting the safety of the livestock industry, the quality of meat ...
Liqun Wang, Guiting Pu, Tingli Liu, Guoliang Chen, Hong Li, Tharheer Oluwashola Amuda, Shanling Cao, Hongbin Yan, Hong Yin, Baoquan Fu, Xuenong Luo   +10 more
wiley   +1 more source