Results 71 to 80 of about 74,570 (280)

Phytol, a Diterpene Alcohol from Chlorophyll, as a Drug against Neglected Tropical Disease Schistosomiasis Mansoni

PLoS Neglected Tropical Diseases, 2014
Background Schistosomiasis is a major endemic disease that affects hundreds of millions worldwide. Since the treatment and control of this parasitic disease rely on a single drug, praziquantel, it is imperative that new effective drugs are developed ...
J. de Moraes, R. N. de Oliveira, Jéssica Pereira Costa, A. L. G. Júnior, D. D. de Sousa, R. Freitas, S. Allegretti, P. L. Pinto   +7 more
semanticscholar   +1 more source

Antibodies to glycans dominate the host response to schistosome larvae and eggs: Is their role protective or subversive? [PDF]

, 2001
Multiple exposures of chimpanzees to the radiation-attenuated schistosome vaccine provoked a strong parasite-specific cellular and humoral immune response. Specific IgM and IgG were directed mainly against glycans on antigens released by cercariae; these
Coulson, P.S., Cummings, R.D., Eberl, M., Langermans, J.A.M., Nyame, A.K., Thomas, A.W., Vervenne, R.A., Wilson, R.A.   +7 more
core   +1 more source

Human Plasma Lipid Modulation in Schistosomiasis Mansoni Depends on Apolipoprotein E Polymorphism

PLoS ONE, 2014
Background Schistosomiasis mansoni is a parasitic liver disease, which causes several metabolic disturbances. Here, we evaluate the influence of Apolipoprotein E (APOE) gene polymorphism, a known modulator of lipid metabolism, on plasma lipid levels in ...
Caíque Silveira Martins da Fonseca, Adenor Almeida Pimenta Filho, B. S. dos Santos, C. A. da Silva, A. Domingues, J. Owen, V. L. de Menezes Lima   +6 more
semanticscholar   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Activity of the artemether in experimental schistosomiasis mansoni [PDF]

Memórias do Instituto Oswaldo Cruz, 1991
The action of the ether of artemisinin (artemether) on Schistosoma mansoni in mice and hamsters experimentally infected with the LE strain was studied. In mice, the drug showed high schistosomicidal activity using a single intramuscular dose of 100 mg/kg/day. By the oral route, this dose showed a low activity.
Araújo, Neusa, Kohn, Anna, Katz, Naftale   +2 more
openaire   +5 more sources

Sustaining control of schistosomiasis mansoni in moderate endemicity areas in western Côte d’Ivoire: a SCORE study protocol

BMC Public Health, 2014
BackgroundSchistosomiasis is a parasitic disease that occurs in the tropics and subtropics. The mainstay of control is preventive chemotherapy with praziquantel. In Africa, an estimated 230 million people require preventive chemotherapy.
Rufin K Assaré, S. Knopp, N. A. N’guessan, A. Yapi, Yves-Nathan T. Tian-Bi, P. Yao, J. Coulibaly, M. Ouattara, Aboulaye Meïté, A. Fenwick, E. N'Goran, J. Utzinger   +11 more
semanticscholar   +1 more source

Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review

British Journal of Pharmacology, EarlyView.
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patients. Inflammation and its resolution, which often differ between sexes, are dysregulated in chronic inflammatory ...
Chloe Landy, Miles J. De Blasio, Owen L. Woodman, Pasquale Maffia, Hong Yong Peh, Cheng Xue Qin   +5 more
wiley   +1 more source

Modelling environmentally-mediated infectious diseases of humans: transmission dynamics of schistosomiasis in China. [PDF]

, 2010
Macroparasites of humans are sensitive to a variety of environmental variables, including temperature, rainfall and hydrology, yet current comprehension of these relationships is limited.
Remais, Justin
core   +1 more source

Pseudotumoral form of cerebral Schistosomiasis Mansoni [PDF]

Journal of Surgical Case Reports, 2012
The authors report a case of 36-year-old woman presented with epileptic seizures and headaches. Magnetic resonance imaging (MRI) revealed an enhancing lesion with surrounding edema and mild mass effect in the left frontal lobe. Stereotactic brain biopsy demonstrated intraparenchymal granulomas surrounding S. mansoni eggs. Praziquantel was started (60mg/
Romero, F. R., Zanini, M. A., Ducati, L. G., Gabarra, R. C., Haddad, G.R., Souza, V. de   +5 more
openaire   +4 more sources

Effects of Video‐Based Health Education on Birth Outcomes and Anaemia Status of Mothers in Dirashe District South Ethiopia: A Cluster Randomized Controlled Trial

Maternal &Child Nutrition, EarlyView.
ABSTRACT Undernutrition and infections during pregnancy result in low birth weight (LBW) and maternal anaemia. Social behaviour change communication (SBCC) can promote recommended health practices, potentially improving maternal and neonatal outcomes.
Wanzahun Godana Boynito, Kidus Temesgen Worsa, Befikadu Tariku Gutema, Yordanos Gizachew Yeshitila, Godana Yaya Tessema, Tsegaye Yohanis, Stefaan De Henauw, Piet Cools, Bruno Levecke, Souheila Abbeddou   +9 more
wiley   +1 more source