Results 71 to 80 of about 73,161 (279)

Activity of the artemether in experimental schistosomiasis mansoni [PDF]

Memórias do Instituto Oswaldo Cruz, 1991
The action of the ether of artemisinin (artemether) on Schistosoma mansoni in mice and hamsters experimentally infected with the LE strain was studied. In mice, the drug showed high schistosomicidal activity using a single intramuscular dose of 100 mg/kg/day. By the oral route, this dose showed a low activity.
Araújo, Neusa, Kohn, Anna, Katz, Naftale   +2 more
openaire   +5 more sources

Human Plasma Lipid Modulation in Schistosomiasis Mansoni Depends on Apolipoprotein E Polymorphism

PLoS ONE, 2014
Background Schistosomiasis mansoni is a parasitic liver disease, which causes several metabolic disturbances. Here, we evaluate the influence of Apolipoprotein E (APOE) gene polymorphism, a known modulator of lipid metabolism, on plasma lipid levels in ...
Caíque Silveira Martins da Fonseca, Adenor Almeida Pimenta Filho, B. S. dos Santos, C. A. da Silva, A. Domingues, J. Owen, V. L. de Menezes Lima   +6 more
semanticscholar   +1 more source

Critical Role of Skin in Pathogenesis: Bidirectional Crosstalk Between Skin and Multiple Organs

MedComm – Future Medicine, Volume 4, Issue 2, June 2025.
The skin functions as both a protective barrier and an autonomous immune organ, maintaining dynamic interactions with internal organs. This review analyzes skin‐organ crosstalk mechanisms, highlighting key cytokines (particularly IL‐17A) and microbial metabolites that mediate interorgan communication.
Wende Deng, Junyi Liu, Changheng Tang, Zhenghao Li, Ying Qiu, Han Zhou, Lanxuan Yang, Ting Li   +7 more
wiley   +1 more source

Pseudotumoral form of cerebral Schistosomiasis Mansoni [PDF]

Journal of Surgical Case Reports, 2012
The authors report a case of 36-year-old woman presented with epileptic seizures and headaches. Magnetic resonance imaging (MRI) revealed an enhancing lesion with surrounding edema and mild mass effect in the left frontal lobe. Stereotactic brain biopsy demonstrated intraparenchymal granulomas surrounding S. mansoni eggs. Praziquantel was started (60mg/
Romero, F. R., Zanini, M. A., Ducati, L. G., Gabarra, R. C., Haddad, G.R., Souza, V. de   +5 more
openaire   +4 more sources

Sustaining control of schistosomiasis mansoni in moderate endemicity areas in western Côte d’Ivoire: a SCORE study protocol

BMC Public Health, 2014
BackgroundSchistosomiasis is a parasitic disease that occurs in the tropics and subtropics. The mainstay of control is preventive chemotherapy with praziquantel. In Africa, an estimated 230 million people require preventive chemotherapy.
Rufin K Assaré, S. Knopp, N. A. N’guessan, A. Yapi, Yves-Nathan T. Tian-Bi, P. Yao, J. Coulibaly, M. Ouattara, Aboulaye Meïté, A. Fenwick, E. N'Goran, J. Utzinger   +11 more
semanticscholar   +1 more source

A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [PDF]

, 2012
Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages.
Allen, JT, Anthony, BJ, Li, Y, McManus, D   +3 more
core   +4 more sources

Endomyocardial fibrosis associated with mansoni schistosomiasis [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2011
Endomyocardial fibrosis (EMF) is a neglected tropical disease that affects millions of people worldwide. EMF is the most common cause of restrictive cardiomyopathy, caused by deposition of fibrous tissue on endocardial surfaces. EMF is a major cause of death in areas where it is endemic, but the pathogenesis of the disease is poorly understood ...
Carneiro, Renata de Carvalho Bicalho, Santos, Alexandre Lemos da Silveira, Brant, Luisa Campos Caldeira, Rabelo, Fábio Tôrres, Ligeiro, Carla Maia, Barcelos, Isabella Peixoto de, Silva, Vanessa Barbosa, Silva, Virgínia Sheila Xavier, Nunes, Maria do Carmo Pereira   +8 more
openaire   +6 more sources

Reduced efficacy of praziquantel against Schistosoma mansoniis associated with multiple rounds of mass drug administration [PDF]

, 2016
Background: Mass drug administration (MDA) with praziquantel is the cornerstone of schistosomiasis control in sub-Saharan Africa. The effectiveness of this strategy is dependent on the continued high efficacy of praziquantel; however, drug efficacy is ...
Cotton, James A., Crellen, Thomas, Kabatereine, Narcis B., Lamberton, Poppy H.L., Tukahebwa, Edridah M., Walker, Martin, Webster, Joanne P.   +6 more
core   +4 more sources

Treatment of Schistosomiasis mansoni with Neostibosan.

Experimental Biology and Medicine, 1946
Twelve patients with ova of 5. mansoni in their stools were treated with the pentavalent antimonial drug, neostibosan (Winthrop). The patients were all males with ages ranging from 15 to 32 years. The drug was administered intravenously during a 2-week period of hospitalization.
Federico Hernandez-Morales, Caroline K. Pratt, José Oliver-González   +2 more
openaire   +3 more sources

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

Journal of Medicinal Chemistry, 2016
Schistosomiasis is a major neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy consists of mass treatment with the only available drug, praziquantel.
T. Heimburg, A. Chakrabarti, Julien Lancelot, M. Marek, Jelena Melesina, Alexander-Thomas Hauser, T. Shaik, S. Duclaud, D. Robaa, F. Erdmann, Matthias Schmidt, C. Romier, R. Pierce, M. Jung, W. Sippl   +14 more
semanticscholar   +1 more source