Results 91 to 100 of about 252,158 (241)

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

open access: yesAdvanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun   +13 more
wiley   +1 more source

Susien paikat. Ihminen ja susi 1900-luvun Suomessa [PDF]

open access: yes, 2022
Viime vuosisadan aikana susien esiintymisessä ja asemassa tapahtui suuria muutoksia. Syntyi monenlaisia käsityksiä susien käyttäytymisestä ja sijoittumisesta. Tässä kirjassa paneudutaan susien paikkoihin 1900-luvun Suomessa.
Heta Lähdesmäki
core  

Distinct Biotypes of Visual Perception in Major Depressive Disorder

open access: yesAdvanced Science, EarlyView.
In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai   +13 more
wiley   +1 more source

schizophrénie et toxicomanie [PDF]

open access: yes, 2015
L‟objectif de ce travail est d‟étudier la fréquence de la comorbidité toxicomaniaque chez les patients schizophrènes, les conséquences de cette comorbidité et de déterminer les facteurs de risques.
Oumiloude, Khaled, Rahmoni, Soufyane
core   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi   +6 more
wiley   +1 more source

Temporal Modulation in Deleuze's Francis Bacon [PDF]

open access: yes, 2019
학위논문(석사)--서울대학교 대학원 :인문대학 미학과,2019. 8. Peter W. Milne.Can "time" be painted? In Francis Bacon: The Logic of Sensation, Deleuze claims that Bacon's painting renders time by stating that, "Time itself is being painted." Yet, how is time "being painted" on ...
조수인
core  

Rüdin's Unpublished Family Study From the Early 1920s: “On the Inheritance of Manic‐Depressive Insanity”

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Ernst Rüdin, an important and controversial figure in the history of psychiatric genetics, published only one major empirical study on siblings of dementia praecox (DP) probands in 1916. He conducted a parallel study of siblings of probands with manic‐depressive insanity (MDI), but the resulting monograph, written in the early 1920s, was left ...
Kenneth S. Kendler, Astrid Klee
wiley   +1 more source

Les déficits cognitifs peuvent-ils aider à distinguer un trouble psychotique avec toxicomanie d’une psychose induite par consommation de méthamphétamines? [PDF]

open access: yes, 2011
Introduction – Dissocié un trouble psychiatrique primaire (TPP) concomitant à un problème d’abus de substances d’une psychose induite par consommation de substance (PICS) peut être une tâche difficile puisque plusieurs symptômes sont similaires.
Bouchard, Vanessa
core  

Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision‐Making and Polygenic Embryo Screening

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome‐wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions.
Lauren A. Ginn   +11 more
wiley   +1 more source

Memorias del II Encuentro de Becarios de Investigación de la Facultad de Psicología de la Universidad Nacional de La Plata [PDF]

open access: yes, 2016
Compilación de ponencias presentadas en el II Encuentro de Becarios de Investigación de la Facultad de Psicología (UNLP).Facultad de ...
Instituto de Investigaciones en Psicología (INIPSI)   +3 more
core   +4 more sources

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