Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
A biophysical network model reveals the link between deficient inhibitory cognitive control and major neurotransmitter and neural connectivity hypotheses in schizophrenia [PDF]
arXiv, 2021 We address a biophysical network dynamical model to study how the modulation of dopamine (DA) activity and related N-methyl-d-aspartate (NMDA) glutamate receptor activity as well as the emerging Pre-Frontal Cortex (PFC) functional connectivity network (FCN) affect inhibitory cognitive function in schizophrenia in an antisaccade task.
arxiv
Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]
, 2012 Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
core +1 more source
The neurophysiology of biological motion perception in schizophrenia. [PDF]
, 2014 IntroductionThe ability to recognize human biological motion is a fundamental aspect of social cognition that is impaired in people with schizophrenia.
Green, Michael F +3 more
core +1 more source
Levomepromazine for Schizophrenia [PDF]
Schizophrenia Bulletin, 2009 Levomepromazine is an ‘older’ typical antipsychotic licensed for use in schizophrenia but sparingly prescribed in the UK. Our objective is to determine the clinical effects and safety of levomepromazine compared with placebo or antipsychotics for schizophrenia and schizophreniform psychoses.
Mahesh Jayaram +2 more
openaire +5 more sources
Comparative genetic architectures of schizophrenia in East Asian and European populations
Nature Genetics, 2018 Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we
Max W. Y. Lam +55 more
semanticscholar +1 more source
Advanced Intelligent Systems, EarlyView.This study, utilizing two large‐cohort datasets, employs interpretable neural networks. It demonstrates that incorporating brain morphology and functional and structural networks enhances predictive accuracy for general psychopathology and its dimensions.
Jing Xia, Nanguang Chen, Anqi Qiu
wiley +1 more source
A Survey on the Role of Artificial Intelligence in the Prediction and Diagnosis of Schizophrenia [PDF]
arXiv, 2023 Machine learning is employed in healthcare to draw approximate conclusions regarding human diseases and mental health problems. Compared to older traditional methods, it can help to analyze data more efficiently and produce better and more dependable results.
arxiv
Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]
, 2010 Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core +2 more sources
A Systematic Review of the Prevalence of Schizophrenia
PLoS Medicine, 2005 Background Understanding the prevalence of schizophrenia has important implications for both health service planning and risk factor epidemiology. The aims of this review are to systematically identify and collate studies describing the prevalence of ...
S. Saha, D. Chant, J. Welham, J. Mcgrath
semanticscholar +1 more source