Results 91 to 100 of about 1,025,722 (378)

Psychosocial and Biological Factors Contributing to Body Weight Gain in Schizophrenia [PDF]

open access: yes, 2011
Overweight and obesity are frequently reported to be a significant issue in schizophrenia resulting in the inherent complications of these disorders.
Pai, NB, Vella, SC
core   +2 more sources

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

open access: yesNature Neuroscience, 2016
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (
M. Fromer   +60 more
semanticscholar   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

open access: yesAdvanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich   +8 more
wiley   +1 more source

Identifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through aging

open access: yesScientific Reports, 2022
The generation of new neurons within the mammalian forebrain continues throughout life within two main neurogenic niches, the subgranular zone (SGZ) of the hippocampal dentate gyrus, and the subependymal zone (SEZ) lining the lateral ventricles.
Mainá Bitar   +9 more
doaj   +1 more source

Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia

open access: yesFrontiers in Psychiatry, 2021
Anhedonia is considered as one of the five dimensions of negative symptoms and mainly refers to the reduction of the capacity of feeling pleasure.
Lingfang Yu   +6 more
doaj   +1 more source

A Systematic Review of the Prevalence of Schizophrenia

open access: yesPLoS Medicine, 2005
Background Understanding the prevalence of schizophrenia has important implications for both health service planning and risk factor epidemiology. The aims of this review are to systematically identify and collate studies describing the prevalence of ...
S. Saha, D. Chant, J. Welham, J. Mcgrath
semanticscholar   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

open access: yesAdvanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu   +9 more
wiley   +1 more source

The effect of training intensity on implicit learning rates in schizophrenia

open access: yesScientific Reports, 2021
Cognitive impairments in learning and memory are core symptoms of schizophrenia, associated with reduced self-reported quality of life. The most effective treatment of cognitive impairments is drill and practice cognitive training.
Natasza D. Orlov   +6 more
doaj   +1 more source

Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]

open access: yes, 2012
Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
core   +1 more source

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? [PDF]

open access: yes, 2017
Growing interest in gut and digestive processes and their potential link to brain and peripheral based inflammation or biobehavioral phenotypes has led to an increasing number of basic and translational scientific reports focused on the role of gut ...
Cadenhead, Kristen S   +4 more
core   +1 more source

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