Results 71 to 80 of about 389,571 (303)
Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients
Frontiers in Neuroscience, 2020 Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade.Helle G. Andersen, Helle G. Andersen, Jayachandra M. Raghava, Jayachandra M. Raghava, Claus Svarer, Sanne Wulff, Louise B. Johansen, Patrick K. Antonsen, Patrick K. Antonsen, Mette Ø. Nielsen, Mette Ø. Nielsen, Egill Rostrup, Anthony C. Vernon, Anthony C. Vernon, Lars T. Jensen, Lars H. Pinborg, Birte Y. Glenthøj, Birte Y. Glenthøj, Bjørn H. Ebdrup, Bjørn H. Ebdrup +19 moredoaj +1 more sourceLipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics [PDF]
, 2013 There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks.Buckley, P, Kaddurah-Daouk, Rima, George G. Dougherty (436720), Peter Buckley (436718), Nasrallah Henry A., Joseph McEvoy, Baillie Rebecca A., Yao Jeffrey K., Nasrallah, HA, Zhu, H, Nasrallah, Henry A., Dougherty, GG, Zhu, Hongjie, Keshavan, Matcheri, Kaddurah-Daouk Rima, Peter Buckley, Keshavan, Matcheri S., Keshavan Matcheri S., Matcheri S Keshavan, Keshavan, MS, George G Dougherty, McEvoy, J, Hongjie Zhu (152174), Dougherty, George G., Henry A Nasrallah, Matcheri S. Keshavan (311472), Rima Kaddurah-Daouk (152187), Buckley Peter, Baillie, RA, McEvoy, Joseph, Hongjie Zhu, Rima Kaddurah-Daouk, McEvoy Joseph, Henry A. Nasrallah (436719), Yao, Jeffrey K., Joseph McEvoy (311475), Buckley, Peter, Kaddurah-Daouk, R, Rebecca A Baillie, Rebecca A. Baillie (152180), Dougherty George G., Jeffrey K Yao, Baillie, Rebecca A., Jeffrey K. Yao (311469), Yao, JK, Zhu Hongjie +45 morecore +1 more sourceAtypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget +6 morewiley +1 more sourcePrimary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis
, 2017 Schizophrenia is a debilitating mental disorder that is associated with an impaired connection of cerebral white matter. Studies on patients with chronic and first-episode schizophrenia have found widespread white matter abnormalities.曾文毅;陳中明;謝明憲;黃宗正;簡意玲;劉智民;劉震鐘;胡海國, Wu, Chen-Hao;Hwang, Tzung-Jeng;Chen, Yu-Jen;Hsu, Yung-Chin;Lo, Yu-Chun;Liu, Chih-Min;Hwu, Hai-Gwo;Liu, Chen-Chung;Hsieh, Ming H.;Chien, Yi-Ling;Chen, Chung-Ming;Tseng, Wen-Yih Isaac +1 morecore +1 more sourceLong‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata +10 morewiley +1 more sourceDeficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia [PDF]
, 2013 Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in Maurer, Konrad, Grützner, Christine, Limin eSun, Wolf Singer, Davide Rivolta, Uhlhaas, Peter J., Michael eWibral, Christine Grützner, Sun, Limin, Konrad Maurer, Davide eRivolta, Singer, Wolf, Maurer, K., Konrad eMaurer, Uhlhaas, P.J., GrÃ1⁄4tzner, Christine, Limin Sun, Uhlhaas, P., Rivolta, Davide, Singer, W. ; https://orcid.org/, Christine Grützner, Rivolta, D., Peter eUhlhaas, Sun, L., Wibral, Michael, Wibral, M., Christine eGruetzner, Wolf eSinger, Michael Wibral, Grützner, C., Peter J. Uhlhaas, Singer, W. +31 morecore +1 more sourceClinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti +18 morewiley +1 more sourceNo Association Evidence between Schizophrenia and Dystrobrevin-Binding Protein 1 (Dtnbp1) in Taiwanese Families
, 2008 Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 ( DTNBP1).劉智民;劉玉麗;范盛娟;楊偉志;鄔哲源;洪舜郁;陳為堅;闕清模;劉偉民;劉震鐘;謝明憲;黃宗正;莊明哲;胡海國, LIU, CHIH-MIN;LIU, YU-LI;FANN, CATHY SHENG-JIUAN;YANG, WEI-CHIH;WU, JER-YUARN;HUNG, SHUEN-IU;CHEN, WEI-JANE;CHUEH, CHING-MO;LIU, WEI-MING;LIU, CHEN-CHUNG;HSIEH, MING-HSIEN;HWANG, TZUNG-JENG;TSUANG, MING T.;HWU, HAI-GWO +1 morecore Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations
Advances in proteomic assay methodologies and genomics have significantly improved our understanding of the blood proteome. Schizophrenia and psychosis risk are linked to polygenic scores for schizophrenia and other mental disorders, as well as to ...Bearden, CE, Walker, E., Corcoran, C, Barbee, J., Kane, J.M., Mongan, D., Perkins, DO, Toben, C, Li, Q.S., Roth, S, Nunez, A.R., Wannan, CMJ, Paul Amminger, G, Mongan, D, Khadimallah, I., Kahn, R.S., Clark, SR, Upthegrove, R, Pasternak, O, Shah, J.L., Billah, T., Martin, AR, Bouix, S, Bearden, C.E., Barbee, J, Khadimallah, I, Walker, E, Martin, A.R., McGorry, PD, Wolf, DH, Li, QS, Do, KQ, Clark, S.R., Do, K.Q., Cerrato, F., Nelson, B., Bleggi, RS, Jeffries, CD, Phassouliotis, C., McGorry, P.D., Calkins, M.E., Shenton, M.E., Shah, JL, Anticevic, A, Nunez, AR, Anticevic, A., Winter-van Rossum, I., Cerrato, F, Bouix, S., Woods, SW, Jeffries, C.D., Shenton, ME, Klauser, P, Billah, T, Cotter, D, Cotter, D., Wolf, D.H., Corcoran, C., Kane, JM, Klauser, P., Calkins, ME, Nelson, B, Wray, N.R., Winter-van Rossum, I, Woods, S.W., Ellman, LM, Perkins, D.O., Upthegrove, R., Roth, S., Phassouliotis, C, Bleggi, R.S., Ellman, L.M., Pasternak, O., Toben, C., Wray, NR, Paul Amminger, G., Kahn, RS +76 morecore +1 more source
