Results 71 to 80 of about 200,189 (245)

Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice

Neuropsychopharmacology Reports
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long‐lasting and difficult to treat.
Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai   +7 more
doaj   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Frontiers in Neuroscience, 2020
Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade.
Helle G. Andersen, Helle G. Andersen, Jayachandra M. Raghava, Jayachandra M. Raghava, Claus Svarer, Sanne Wulff, Louise B. Johansen, Patrick K. Antonsen, Patrick K. Antonsen, Mette Ø. Nielsen, Mette Ø. Nielsen, Egill Rostrup, Anthony C. Vernon, Anthony C. Vernon, Lars T. Jensen, Lars H. Pinborg, Birte Y. Glenthøj, Birte Y. Glenthøj, Bjørn H. Ebdrup, Bjørn H. Ebdrup   +19 more
doaj   +1 more source

Systematic Cardiac Phenotyping of Patients With Copy Number Variants in the 15q11.2 Breakpoint 1 to Breakpoint 2 Region: A Retrospective Cohort Study From Nine Pediatric Cardiac Centers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Microdeletions impacting 15q11.2 breakpoint (BP) 1 to BP2, adjacent to the Prader–Willi critical region, have previously described neuropsychiatric associations, with potential low penetrance presentations of congenital heart disease (CHD) also identified.
Morgan B. Wright, Maria B. Padua, Lindsey R. Helvaty, Kim L. McBride, Gabrielle Geddes, Vidu Garg, Seema R. Lalani, Stephanie Burns Wechsler, Jennelle C. Hodge, Benjamin J. Landis, Stephanie M. Ware   +10 more
wiley   +1 more source

Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations

Advances in proteomic assay methodologies and genomics have significantly improved our understanding of the blood proteome. Schizophrenia and psychosis risk are linked to polygenic scores for schizophrenia and other mental disorders, as well as to ...
Bearden, CE, Walker, E., Corcoran, C, Barbee, J., Kane, J.M., Mongan, D., Perkins, DO, Toben, C, Li, Q.S., Roth, S, Nunez, A.R., Wannan, CMJ, Paul Amminger, G, Mongan, D, Khadimallah, I., Kahn, R.S., Clark, SR, Upthegrove, R, Pasternak, O, Shah, J.L., Billah, T., Martin, AR, Bouix, S, Bearden, C.E., Barbee, J, Khadimallah, I, Walker, E, Martin, A.R., McGorry, PD, Wolf, DH, Li, QS, Do, KQ, Clark, S.R., Do, K.Q., Cerrato, F., Nelson, B., Bleggi, RS, Jeffries, CD, Phassouliotis, C., McGorry, P.D., Calkins, M.E., Shenton, M.E., Shah, JL, Anticevic, A, Nunez, AR, Anticevic, A., Winter-van Rossum, I., Cerrato, F, Bouix, S., Woods, SW, Jeffries, C.D., Shenton, ME, Klauser, P, Billah, T, Cotter, D, Cotter, D., Wolf, D.H., Corcoran, C., Kane, JM, Klauser, P., Calkins, ME, Nelson, B, Wray, N.R., Winter-van Rossum, I, Woods, S.W., Ellman, LM, Perkins, D.O., Upthegrove, R., Roth, S., Phassouliotis, C, Bleggi, R.S., Ellman, L.M., Pasternak, O., Toben, C., Wray, NR, Paul Amminger, G., Kahn, RS   +76 more
core   +1 more source

Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation

Translational Psychiatry
Elevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length ...
Jessica J. Chandra, Yunting Zhu, Alice Petty, Yasmine Kostoglou, William X. Haynes, Maree J. Webster, Cynthia S. Weickert   +6 more
doaj   +1 more source

Genetic Variation in ADHD‐Related Risk Genes in an Indigenous Population of the Amazon

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Attention‐Deficit/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental disorder; however, its genetic architecture remains poorly explored in Indigenous populations. This study aimed to analyze and characterize genetic variation in 11 genes (ADGRL3, CDH8, DCC, DUSP6, FOXP1, FOXP2, MEF2C, PCDH7, SEMA6D, SORCS3, and ST3GAL3 ...
Hirlesson Paixão de Matos, Natasha Monte, Kaio Evandro Cardoso Aguiar, Rita de Cássia Calderaro, Aline Pasquini Santos, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐Dos‐Santos, Sandro José De Souza, Ândrea Ribeiro‐Dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista Dos Santos, Ney Pereira Carneiro Dos Santos   +11 more
wiley   +1 more source

BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation

Frontiers in Cellular Neuroscience, 2014
The SH-SY5Y culture system is a convenient neuronal model with the potential to elaborate human/primate-specific transcription networks and pathways related to human cognitive disorders.
Belinda J Goldie, Belinda J Goldie, Michelle M Barnett, Murray J Cairns, Murray J Cairns   +4 more
doaj   +1 more source

Mental Health Stigma in Psychiatric Genetics: Insights and Recommendations From the ISPG Member Survey on Stigma

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Little is known about how stigma is perceived within psychiatric genetics, a field increasingly central to public discussions about heredity, neurodiversity, and psychiatric risk. Understanding how stigma is perceived and experienced by psychiatric geneticists is important for guiding responsible communication and future stigma‐reduction ...
Anaïs B. Thijssen, Elleke Tissink, Reeteka Sud, Mandy Johnstone, Richard Josiassen, Andrea Lahti, Laura Huckins, Ariana Page, Stigma Reduction Interest Group of the ISPG, Jordan W. Smoller, Jehannine Austin, Janneke Zinkstok, Sarah E. Medland, Rada Veeneman, Anna R. Docherty   +14 more
wiley   +1 more source

No Association Evidence between Schizophrenia and Dystrobrevin-Binding Protein 1 (Dtnbp1) in Taiwanese Families

, 2008
Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 ( DTNBP1).
劉智民;劉玉麗;范盛娟;楊偉志;鄔哲源;洪舜郁;陳為堅;闕清模;劉偉民;劉震鐘;謝明憲;黃宗正;莊明哲;胡海國, LIU, CHIH-MIN;LIU, YU-LI;FANN, CATHY SHENG-JIUAN;YANG, WEI-CHIH;WU, JER-YUARN;HUNG, SHUEN-IU;CHEN, WEI-JANE;CHUEH, CHING-MO;LIU, WEI-MING;LIU, CHEN-CHUNG;HSIEH, MING-HSIEN;HWANG, TZUNG-JENG;TSUANG, MING T.;HWU, HAI-GWO   +1 more
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