Results 61 to 70 of about 693,765 (295)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

The impact of schizophrenia and intelligence on the relationship between age and brain volume

Schizophrenia Research: Cognition, 2019
Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline in schizophrenia compared to healthy controls.
Maria H. Jensen, Nikolaj Bak, Egill Rostrup, Mette Ø. Nielsen, Christos Pantelis, Birte Y. Glenthøj, Bjørn H. Ebdrup, Birgitte Fagerlund   +7 more
doaj   +1 more source

Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy

Frontiers in Psychiatry, 2020
Objective: Previous studies consistently showed the interaction between Sirtuin 1 (SIRT1) and immune inflammation is significantly related to metabolic abnormalities, but their role in the pathogenesis of metabolic syndrome caused by second-generation ...
Xinyu Fang, Xinyu Fang, Lingfang Yu, Dandan Wang, Yan Chen, Yewei Wang, Zenan Wu, Ruimei Liu, Juanjuan Ren, Wei Tang, Chen Zhang   +10 more
doaj   +1 more source

On the descriptive validity of ICD-10 schizophrenia: Empirical analyses in the spectrum of non-affective functional psychoses [PDF]

, 2003
In order to examine the descriptive validity of ICD-10 schizophrenia, 1,476 consecutively admitted in-patients were included in the present study. ICD-10 schizophrenia (n = 951) was compared with other non-affective psychotic disorders {[}persistent ...
Bottlender, Ronald, Jäger, Markus, Möller, Hans-Jürgen, Strauss, Anton   +3 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Carbonyl Stress and Microinflammation-Related Molecules as Potential Biomarkers in Schizophrenia

Frontiers in Psychiatry, 2018
This literature review primarily aims to summarize our research, comprising both cross-sectional and longitudinal studies, and discuss the possibility of using microinflammation-related biomarkers as peripheral biomarkers in the diagnosis and monitoring ...
Tohru Ohnuma, Shohei Nishimon, Mayu Takeda, Takahiro Sannohe, Narimasa Katsuta, Heii Arai   +5 more
doaj   +1 more source

Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments

BMC Psychiatry, 2023
Background Cognitive impairment is the main factor in the poor prognosis of schizophrenia, but its mechanism remains unclear. The inferior parietal lobule (IPL) is related to various clinical symptoms and cognitive impairment in schizophrenia.
Xiao-Fan Liu, Shu-Wan Zhao, Jin-Jin Cui, Yue-Wen Gu, Jing-Wen Fan, Yu-Fei Fu, Ya-Hong Zhang, Hong Yin, Kun Chen, Long-Biao Cui   +9 more
doaj   +1 more source

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. [PDF]

, 2013
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia.
A D Børglum, A Hedemand, A Ludwig, A Miyashita, A Terracciano, A Uitterlinden, AC Need, AC Ravanpay, AD Skol, AG Cardno, AR Fisher, AR Morgan, AS Brown, AS Brown, AS Yap, B Janssens, B Nørgaard-Pedersen, B Xu, BH Shirts, BJ Fredette, BM Gumbiner, BM Neale, BM Neale, C B Pedersen, C Ciatto, C Wiuf, CB Pedersen, CE Murcray, CM Nievergelt, D Demontis, D Demontis, D M Hougaard, D Moreno-De-Luca, DB Boivin, GR Abecasis, H Le-Niculescu, H Stefansson, H Stefansson, HA Mansour, HA Mansour, HC So, I Sousa, J Grove, J Lasky-Su, J Majercak, J Novembre, J Pallesen, J Shi, J van Os, J Yang, JA Embil, JE Buizer-Voskamp, JJ Kim, K Wang, K Wulff, K Zhou, KH Baratz, KP Lesch, L Athanasiu, LN Moens, M Didriksen, M M Nöthen, M Mattheisen, M Nordentoft, M Nyegaard, M Nyegaard, M Rietschel, M Rietschel, M Scholz, M Takeichi, M Takeichi, M V Hollegaard, ML Rao, MS Keshavan, MV Hollegaard, N Cermakian, N Patterson, O Mors, O Mors, P B Mortensen, PA Holmans, PB Mortensen, PF Sullivan, R A Ophoff, R H Yolken, R Steinberg, RL Schelonka, S Cichon, S Purcell, S Ripke, S Steinberg, SA Riazuddin, SA Staras, SH Lee, SJ Sanders, SL Buka, SL Buka, SM Purcell, T Miyoshi, T Takeuchi, T Ørntoft, TJ Crow, TL Edwards, V Busby, V Soria, VR Sobrado, X Liang, Y Adachi, Y Li   +108 more
core   +4 more sources

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Functional network changes and cognitive control in schizophrenia [PDF]

, 2017
Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of ...
Barch, Deana M, Carter, Cameron S, Gold, James M, Howell, Amber M, Lesh, Tyler A, MacDonald, Angus W, Ragland, J. Daniel, Ray, Kimberly L, Salo, Taylor P, Silverstein, Steven M   +9 more
core   +9 more sources