Results 61 to 70 of about 389,571 (303)

Avatar Therapy for people with schizophrenia or related disorders

, 2020
BackgroundMany people with schizophrenia do not achieve satisfactory improvements in their mental state, particularly the symptom of hearing voices (hallucinations), with medical treatment.ObjectivesTo examine the effects of Avatar Therapy for people ...
Aali, Ghazaleh, Shokraneh, Farhad, Kariotis, Timothy, Aali, G, Shokraneh, F, Kariotis, T   +5 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments

BMC Psychiatry, 2023
Background Cognitive impairment is the main factor in the poor prognosis of schizophrenia, but its mechanism remains unclear. The inferior parietal lobule (IPL) is related to various clinical symptoms and cognitive impairment in schizophrenia.
Xiao-Fan Liu, Shu-Wan Zhao, Jin-Jin Cui, Yue-Wen Gu, Jing-Wen Fan, Yu-Fei Fu, Ya-Hong Zhang, Hong Yin, Kun Chen, Long-Biao Cui   +9 more
doaj   +1 more source

Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring [PDF]

, 2009
Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal functional integration of brain processes.
Friston, K J, Frith, C D, Frith, C. D., Stephan, K E, Stephan, K. E., Friston, K. J.   +5 more
core   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Epidural auditory event-related potentials in the rat to frequency and duration deviants: evidence of mismatch negativity?

Frontiers in Psychology, 2011
The capacity of the human brain to detect deviance in the acoustic environment pre-attentively is reflected in a brain event-related potential (ERP), mismatch negativity (MMN).
Tamo eNakamura, Tamo eNakamura, Tamo eNakamura, Tamo eNakamura, Patricia T Michie, Patricia T Michie, Patricia T Michie, Patricia T Michie, William R Fulham, William R Fulham, William R Fulham, William R Fulham, Juanita eTodd, Juanita eTodd, Juanita eTodd, Juanita eTodd, Timothy W Budd, Timothy W Budd, Timothy W Budd, Timothy W Budd, Ulrich eSchall, Ulrich eSchall, Ulrich eSchall, Ulrich eSchall, Michael eHunter, Michael eHunter, Deborah M Hodgson, Deborah M Hodgson, Deborah M Hodgson, Deborah M Hodgson   +29 more
doaj   +1 more source

Estrogens and gonadal function in schizophrenia and related psychoses [PDF]

, 2011
Recent research has increasingly pointed to the importance of estrogens and the hypothalamic-pituitary-gonadal axis in schizophrenia. Specifically, there is mounting evidence from clinical, epidemiological, and basic research that estradiol, the main ...
Riecher-Rössler, Anita, Kulkarni, Jayashri   +1 more
core  

Dimensions of the AI Divide: Digital Inequality and Psychological Consequences

AI &Innovation, EarlyView.
ABSTRACT Artificial intelligence (AI) has become a foundational component of contemporary social, economic, and political life. Yet, the ways in which AI reshapes patterns of exclusion beyond questions of access and technical capability remain insufficiently theorized.
Christos Papaioannou
wiley   +1 more source

Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice

Neuropsychopharmacology Reports
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long‐lasting and difficult to treat.
Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai   +7 more
doaj   +1 more source

BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation

Frontiers in Cellular Neuroscience, 2014
The SH-SY5Y culture system is a convenient neuronal model with the potential to elaborate human/primate-specific transcription networks and pathways related to human cognitive disorders.
Belinda J Goldie, Belinda J Goldie, Michelle M Barnett, Murray J Cairns, Murray J Cairns   +4 more
doaj   +1 more source