Results 121 to 130 of about 389,571 (303)

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Structural and functional connectivity in relation to executive functions in antipsychotic-naïve patients with first episode schizophrenia

Schizophrenia
Patients with schizophrenia exhibit structural and functional dysconnectivity but the relationship to the well-documented cognitive impairments is less clear.
Tina D. Kristensen, Karen S. Ambrosen, Jayachandra M. Raghava, Warda T. Syeda, Thijs Dhollander, Cecilie K. Lemvigh, Kirsten B. Bojesen, Anita D. Barber, Mette Ø. Nielsen, Egill Rostrup, Christos Pantelis, Birgitte Fagerlund, Birte Y. Glenthøj, Bjørn H. Ebdrup   +13 more
doaj   +1 more source

Metabolic Syndrome and Schizophrenia: Adding a Piece to the Interplay Between the Kynurenine Pathway and Inflammation

Metabolites
The biology of schizophrenia is highly complex and multifaceted. Numerous efforts have been made over the years to disentangle the heterogeneity of the disease, gradually leading to a more detailed understanding of its underlying pathogenic mechanisms ...
Jacopo Sapienza, Giulia Agostoni, Federica Repaci, Marco Spangaro, Stefano Comai, Marta Bosia   +5 more
doaj   +1 more source

Source monitoring and memory confidence in schizophrenia

, 2003
BACKGROUND: The present study attempted to extend previous research on source monitoring deficits in schizophrenia. We hypothesized that patients would show a bias to attribute self-generated words to an external source. Furthermore, it was expected that
S. Moritz, T. S. Woodward, Woodward, T.S., C. C. Ruff, Ruff, C.C., Moritz, S.   +5 more
core  

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

A Commentary on “Comparing Operationalizations of Eating Disorder Recovery Using a Comprehensive Lens: Physical, Behavioral, and Cognitive Domains” by Bardone‐Cone et al.

International Journal of Eating Disorders, EarlyView.
ABSTRACT Defining recovery in eating disorders remains a major challenge due to the absence of standardized, empirically validated criteria. Bardone‐Cone et al. (2025) address this gap by testing multidimensional, transdiagnostic recovery criteria spanning physical, behavioral, and cognitive domains.
Charlotte Bovenberg, Suman Ambwani, Valentina Cardi, Janet Treasure   +3 more
wiley   +1 more source

Cognition impairment in schizophrenia patients with tardive dyskinesia: Association with plasma superoxide dismutase activity

, 2014
Long-term antipsychotic treatment for schizophrenia is often associated with the emergence of tardive dyskinesia (TD), and TD presence is also accompanied by more severe cognitive impairment.
Tan, Yun Long, Wu, Jing Qin, Chen, Da Chun, Zhang, Xiang Yang, Yang, Fu De, Xiu, Mei Hong, Tan, Shu Ping, Wang, Zhi Ren   +7 more
core   +1 more source

Psychiatric Morbidity Is Overrepresented in Young Girls at High Risk of Developing Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is relatively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial high risk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding ...
Karin Dahlin, Kajsa Järvholm, Jovanna Dahlgren, Elisabet Wentz   +3 more
wiley   +1 more source

Emotional intelligence in schizophrenia

, 2008
Deficits in emotion perception have been extensively documented in schizophrenia and are associated with poor psychosocial functioning. However, little is known about other aspects of emotion processing that are critical for adaptive functioning.
Robert S. Kern, William P. Horan, Peter Salovey, Kenneth L. Subotnik, Catherine A. Sugar, Kimmy S. Kee, Mark J. Sergi, Keith Nuechterlein, Junghee Lee, Alan P. Fiske, Michael F. Green   +10 more
core  

When Is Improvement Possible? A Necessity‐Based Analysis of Short‐Term Eating Disorder Symptom Improvement During Inpatient Treatment

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating‐disorder–specific functional impairment may represent a boundary condition for treatment response, yet this possibility has rarely been examined. We investigated whether baseline functional impairment constrains short‐term eating‐disorder symptom improvement, indexed by change in EDE‐Q Global scores during inpatient treatment ...
Paolo Meneguzzo, Patrizia Todisco
wiley   +1 more source