Results 131 to 140 of about 821,521 (329)

Development of New Benzo[b]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists

ChemMedChem, EarlyView.
A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin, Matthieu Hedouin, Christophe Furman, Ophélie Not, Steve Lancel, Mona Bensalah, Gael Coadou, Eric Boulanger, Sergiu Shova, Hassan Oulyadi, Alina Ghinet   +10 more
wiley   +1 more source

Metabolic Syndrome and Schizophrenia: Adding a Piece to the Interplay Between the Kynurenine Pathway and Inflammation

Metabolites
The biology of schizophrenia is highly complex and multifaceted. Numerous efforts have been made over the years to disentangle the heterogeneity of the disease, gradually leading to a more detailed understanding of its underlying pathogenic mechanisms ...
Jacopo Sapienza, Giulia Agostoni, Federica Repaci, Marco Spangaro, Stefano Comai, Marta Bosia   +5 more
doaj   +1 more source

Multifamily groups for patients with schizophrenia: an exploratory randomised controlled trial in Bosnia and Herzegovina [PDF]

, 2022
M. Muhić, Slobodan Јаnkovic, Hana Sikira, S. Slatina Murga, Michael McGrath, Catherine Fung, Stefan Priebe, Alma Džubur Kulenović   +7 more
openalex   +1 more source

Engineering Liposomes for Neurodegenerative Diseases: Targeted Delivery and Regenerative Potential

ChemNanoMat, EarlyView.
Liposomal nanocarriers offer therapeutic promise for neurodegenerative diseases by encapsulating diverse agents such as neurotrophic factors and mRNA while targeting the blood‐brain barrier. Designed to stimulate neuronal repair and restore function, these lipid vesicles advance strategies for optimized design and central nervous system delivery ...
Oybek Ashirov, Shakhnoz Azimova, Borislav Angelov, Angelina Angelova   +3 more
wiley   +1 more source

GenoStaR: An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety.
Alex J. Coulter, Megana Thamilselvan, James L. Kennedy, Clement C. Zai, Arun K. Tiwari   +4 more
wiley   +1 more source

The economic burden of schizophrenia [PDF]

, 1990
Linda Davies, Michael Drummond
openalex   +1 more source

Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150glued [PDF]

, 2021
Bo Kyoung Suh, Seol‐Ae Lee, Cana Park, Yeongjun Suh, Soo Jeong Kim, Young Sik Woo, Truong Thi My Nhung, Su Been Lee, Dong Jin Mun, Bon Seong Goo, Hyun Sun Choi, So Jung Kim, Sang Ki Park   +12 more
openalex   +1 more source

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang, M. A. Magateshvaren Saras, K. Conn, E. Greaves, F. Reed, S. Tyagi, H. Munguba, C. J. Foldi   +7 more
wiley   +1 more source

Effectiveness of Remote Family Education and Support Program for Parents of Adolescents With Eating Disorders Based on Interpersonal Psychotherapy: A Randomized Controlled Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Given the frequent conflict between parents and adolescents with eating disorders, we aimed to develop a remote family education and support program (rFESP) for parents based on the principles of interpersonal psychotherapy (IPT) and investigate its effect on promoting effective communication at home.
Fujika Katsuki, Hanayo Sawada, Yuka Kawasaki, Masaki Kondo, Atsurou Yamada, Norio Watanabe   +5 more
wiley   +1 more source

The Tamil Version of the Three-Factor Eating Questionnaire-R18V2: Reliability and Factor Structure Among Persons with Schizophrenia

Indian Journal of Psychological Medicine
Background: Persons with schizophrenia (PwS) are vulnerable to developing disordered eating behaviors. However, standardized tools to assess disordered eating patterns are unavailable in the regional language, Tamil.
G. Swarnameenaa, Jothilakshmi Durairaj, Nithyashri Hariharan, Vaishnavi K. Madhavan, Pavithra Arunachaleeswaran, Lakshmi Venkatraman, Anoop Sankaranarayanan, Padmavati Ramachandran   +7 more
doaj   +1 more source