Results 131 to 140 of about 1,025,722 (378)

Rare coding variants in ten genes confer substantial risk for schizophrenia

Nature, 2022
T. Singh, T. Poterba, D. Curtis, H. Akil, M. A. Al Eissa, J. Barchas, N. Bass, T. Bigdeli, G. Breen, E. Bromet, Peter F. Buckley, W. Bunney, J. Bybjerg-Grauholm, W. Byerley, S. Chapman, Wei J. Chen, C. Churchhouse, N. Craddock, C. Cusick, L. DeLisi, S. Dodge, M. Escamilla, S. Eskelinen, A. Fanous, S. Faraone, A. Fiorentino, L. Francioli, S. Gabriel, D. Gage, S. G. Gagliano Taliun, A. Ganna, G. Genovese, D. Glahn, J. Grove, M. Hall, E. Hämäläinen, H. Heyne, M. Holi, D. Hougaard, D. Howrigan, Hailiang Huang, H. Hwu, R. Kahn, H. Kang, K. Karczewski, G. Kirov, J. Knowles, F. Lee, D. Lehrer, F. Lescai, D. Malaspina, S. Marder, S. Mccarroll, A. McIntosh, H. Medeiros, L. Milani, C. Morley, D. Morris, P. Mortensen, R. Myers, M. Nordentoft, N. O’Brien, A. M. Olivares, D. Ongur, W. Ouwehand, D. Palmer, T. Paunio, D. Quested, M. Rapaport, E. Rees, B. Rollins, F. Satterstrom, A. Schatzberg, E. Scolnick, L. Scott, Sally Sharp, P. Sklar, J. Smoller, J. Sobell, M. Solomonson, E. Stahl, C. Stevens, J. Suvisaari, G. Tiao, S. Watson, N. Watts, D. Blackwood, A. Børglum, B. Cohen, A. Corvin, T. Esko, N. Freimer, S. Glatt, C. Hultman, A. McQuillin, A. Palotie, C. Pato, M. Pato, A. Pulver, D. St. Clair, M. Tsuang, M. Vawter, J. Walters, T. Werge, R. Ophoff, Patrick F. Sullivan, M. Owen, M. Boehnke, M. O’Donovan, B. Neale, M. Daly   +110 more
semanticscholar   +1 more source

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Electrochemistry as a Tool for Redox‐Based Bio‐Information Processing

Advanced Science, EarlyView.
Redox is a modality that is native to biology and accessible to electronics through electrochemistry. Imposed electronic inputs are transduced into redox signals that can probe for bio‐information or actuate biological responses. Measured electronic output responses are analyzed to reveal actionable information.
Eunkyoung Kim, Chen‐yu Chen, Fauziah Rahma Zakaria, Dana Motabar, Mijeong Kang, Deanna L. Kelly, Alessandra Napolitano, William E. Bentley, Gregory F. Payne   +8 more
wiley   +1 more source

Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders

Frontiers in Psychiatry
BackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear.
Umit Haluk Yesilkaya, Umit Haluk Yesilkaya, Xi Chen, Xi Chen, Lauren Watford, Emma McCoy, Meltem Sen, Ilgin Genc, Fei Du, Fei Du, Dost Ongur, Dost Ongur, Cagri Yuksel, Cagri Yuksel   +13 more
doaj   +1 more source

What does a mouse tell us about neuregulin 1 – cannabis interactions?

Frontiers in Cellular Neuroscience, 2013
The link between cannabis and psychosis has been debated although there is substantial epidemiological evidence showing that cannabis increases the risk of psychosis.
Tim eKarl, Tim eKarl, Tim eKarl, Jonathon Carl Arnold, Jonathon Carl Arnold, Jonathon Carl Arnold   +5 more
doaj   +1 more source

Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia. [PDF]

, 2018
Reduced fractional anisotropy (FA) is a well-established correlate of schizophrenia, but it remains unclear whether these tensor-based differences are the result of axon damage and/or organizational changes and whether the changes are progressive in the ...
Bearden, Carrie E, Cannon, Tyrone D, Grazioplene, Rachael G, Haut, Kristen, Nuechterlein, Keith H, Subotnik, Kenneth L, Ventura, Joseph   +6 more
core   +3 more sources

Global economic burden of schizophrenia: a systematic review

Neuropsychiatric Disease and Treatment, 2016
Background Schizophrenia is one of the top 25 leading causes of disability worldwide in 2013. Despite its low prevalence, its health, social, and economic burden has been tremendous, not only for patients but also for families, caregivers, and the wider ...
H. Chong, S. Teoh, D. Wu, Surachai Kotirum, C. Chiou, N. Chaiyakunapruk   +5 more
semanticscholar   +1 more source

Unraveling Multimodal Brain Signatures: Deciphering Transdiagnostic Dimensions of Psychopathology in Adolescents

Advanced Intelligent Systems, EarlyView.
This study, utilizing two large‐cohort datasets, employs interpretable neural networks. It demonstrates that incorporating brain morphology and functional and structural networks enhances predictive accuracy for general psychopathology and its dimensions.
Jing Xia, Nanguang Chen, Anqi Qiu
wiley   +1 more source

Correction to: Skating on thin ice: pragmatic prescribing for medication refractory schizophrenia

BMC Psychiatry, 2019
After publication of the original article [1], the authors have notified us that there was an oversight on acknowledging funding received for the study. They would like to mention that Professor Sukhi Shergill was funded by an ERC Consolidator Award.
Derek K. Tracy, Dan W. Joyce, S. Neil Sarkar, Maria-Jesus Mateos Fernandez, Sukhwinder S. Shergill   +4 more
doaj   +1 more source

What is schizophrenia?

Schizophrenia bulletin, 2019
Many who pick up this book will be learning about schizophrenia for the first time, either because someone they care about has recently been diagnosed, or purely out of academic interest.
J. S. Strauss, M. B. Bowers, S. J. Keith, J. Wing   +3 more
semanticscholar   +1 more source