Results 211 to 220 of about 389,571 (303)

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Towards an integrative and personalized care across the stages of schizophrenia spectrum disorders. [PDF]

World Psychiatry
Krebs MO.
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Urinary organic acid levels and their associations with clinical characteristics in patients with schizophrenia. [PDF]

Metabolomics
Yılmaz Y, Doğan HO, Murat A, Zararsız G.   +3 more
europepmc   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Mental Health Risk Factors for Postoperative Pain in Head and Neck Free Flap Reconstruction Patients

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Head and neck cancer (HNC) surgery is associated with postoperative pain and comorbid mental health disorders (MHDs). This study assessed predictors of postoperative pain and inpatient pain service consultation following free flap reconstruction (FFR). Study Design Retrospective cohort. Setting Single‐institution database.
Daniel R. S. Habib, Sindhura Sridhar, Heezy Suh, Daniel Larson, Brooke B. Swain, Kelly Vittetoe, Donald Sengstack, Michael C. Topf, Melanie D. Hicks   +8 more
wiley   +1 more source

Stigmatising Attitudes Towards People With Depression, Bipolar Disorder, Borderline Personality, ADHD and Early and Long-Term/Untreated Schizophrenia: Representative Survey of Australian Adults. [PDF]

Med J Aust
Morgan AJ, Ross AM, McNaught G, Green R, Reavley NJ.   +4 more
europepmc   +1 more source

Schizophrenia

International Journal of Clinical Practice, 1958
openaire   +2 more sources