Results 21 to 30 of about 690,232 (374)

Biallelic GTF2IRD1 variants in brothers with profound neurodevelopmental disorder: A possible novel disorder involving a critical gene for Williams syndrome

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 332-337, February 2023., 2023
Abstract GTF2IRD1, a gene on chromosome 7 which encodes a transcription factor, is of significant clinical interest due to its heterozygous loss as part of the classical deletion associated with Williams–Beuren syndrome (WBS). However, biallelic variants in GTF2IRD1 alone as part of an autosomal recessive disease have not been previously reported. Here,
Christopher Thomas Cummings, Lois Janelle Starr   +1 more
wiley   +1 more source

The search for new biomarkers for cognition in schizophrenia

Schizophrenia Research: Cognition, 2015
The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and ...
Rafael Penadés, Clemente García-Rizo, Miquel Bioque, Alexandre González-Rodríguez, Bibiana Cabrera, Gisela Mezquida, Miquel Bernardo   +6 more
doaj   +1 more source

The developmental trajectories of the behavioral phenotype and neuropsychiatric functioning in Cornelia de Lange and Rubinstein Taybi syndromes: A longitudinal study

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 424-436, February 2023., 2023
Abstract Several changes in the behavioral phenotype arise with the growth of children affected by Cornelia de Lange Syndrome (CdLS) and Rubinstein‐Taybi Syndrome (RSTS). However, previous research relied on a cross‐sectional study design turning into age‐related comparisons of different syndromic cohorts to explore age‐dependent changes.
Paola Francesca Ajmone, Ludovica Giani, Beatrice Allegri, Giovanni Michelini, Francesca Dall'Ara, Claudia Rigamonti, Federico Monti, Paola Giovanna Vizziello, Angelo Selicorni, Donatella Milani, Simona Scaini, Antonella Costantino   +11 more
wiley   +1 more source

Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: A support vector machine learning approach

NeuroImage: Clinical, 2014
Heterogeneity in the structural brain abnormalities associated with schizophrenia has made identification of reliable neuroanatomical markers of the disease difficult.
Ian C. Gould, Alana M. Shepherd, Kristin R. Laurens, Murray J. Cairns, Vaughan J. Carr, Melissa J. Green   +5 more
doaj   +1 more source

A nation-wide twin study of social cognition in schizophrenia spectrum disorders

npj Schizophrenia, 2022
We examined social cognition in 32 monozygotic (MZ) and 21 dizygotic (DZ) twin pairs concordant or discordant for a schizophrenia spectrum diagnosis and healthy control (HC) twin pairs (29 MZ/20 DZ).
Cecilie K. Lemvigh, Birte Y. Glenthøj, Birgitte Fagerlund   +2 more
doaj   +1 more source

Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia

Frontiers in Immunology, 2022
Deficit schizophrenia (DS) patient is a homogenous subtype of schizophrenia that includes primary and enduring negative symptoms. This study aimed to compare the differences in cognitive functioning and plasma levels of C-reactive protein (CRP) and ...
Dandan Wang, Yewei Wang, Yan Chen, Lingfang Yu, Zenan Wu, Ruimei Liu, Juanjuan Ren, Xinyu Fang, Chen Zhang   +8 more
doaj   +1 more source

Schizophrenia and the Dysfunctional Brain [PDF]

, 2010
Scientists, philosophers, and even the lay public commonly accept that schizophrenia stems from a biological or internal ‘dysfunction.’ However, this assessment is typically accompanied neither by well-defined criteria for ...
Garson, Justin
core   +1 more source

Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia [PDF]

, 2014
Neurodevelopmental processes are widely believed to underlie schizophrenia. Analysis of brain texture from conventional magnetic resonance imaging (MRI) can detect disturbance in brain cytoarchitecture.
American Psychiatric Association, Andreasen, Annese, Arnold, Ashburner, Balaji Ganeshan, Cannon, Cannon, Chang, Chris Chatwin, de Oliveira, Eickhoff, Eugenia Radulescu, Fischl, Fornito, Ganeshan, Ganeshan, Goghari, Goldman, Gothelf, Gottesman, Groeschel, Gustavsson, Hafner, Harrison, Harrison, Harrison, Hilgetag, Hof, Honea, Hugo D. Critchley, Kassner, Kawasaki, Keshavan, Kovalev, Kubota, Kuhn, Kuperberg, Lemaitre, Mangin, Matthews, Meyer-Lindenberg, Nelson, Nesvag, Nick Medford, O’Daly, Prasad, Psychiatric Genomics Consortium, Qiu, Radulescu, Rasetti, Reif, Ridgway, Rimol, Rogers, Rorden, Rupert C.D. Young, Sanz-Cortes, Schmitt, Shenton, Shepherd, Sukhwinder S. Shergill, Tamminga, Theocharakis, Uranova, Van Essen, Weinberger, Weinberger, White, Wiegand, Wright, Yoon, Zhang, Zierhut   +73 more
core   +1 more source

Serotonin and schizophrenia [PDF]

, 2010
Abstract Although the serotonin hypothesis of schizophrenia is one of the oldest neurochemical hypotheses on the pathogenesis of the disease, it is still topical. The concept of how the serotonin system is involved in the origin and progress of schizophrenia has changed considerably over the past decades.
Quednow, Boris B, Geyer, Mark A, Halberstadt, Adam L   +2 more
openaire   +2 more sources

Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial

BMC Psychiatry, 2021
Background Cannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized ...
Jesper Østrup Rasmussen, Poul Jennum, Kristian Linnet, Birte Y. Glenthøj, Lone Baandrup   +4 more
doaj   +1 more source