Results 21 to 30 of about 687,888 (183)

A nation-wide twin study of social cognition in schizophrenia spectrum disorders

npj Schizophrenia, 2022
We examined social cognition in 32 monozygotic (MZ) and 21 dizygotic (DZ) twin pairs concordant or discordant for a schizophrenia spectrum diagnosis and healthy control (HC) twin pairs (29 MZ/20 DZ).
Cecilie K. Lemvigh, Birte Y. Glenthøj, Birgitte Fagerlund   +2 more
doaj   +1 more source

Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies. [PDF]

, 2018
AimThe hippocampus is considered a key region in schizophrenia pathophysiology, but the nature of hippocampal subregion abnormalities and how they contribute to disease expression remain to be fully determined.
Matsumoto, Mitsuyuki, Nakahara, Soichiro, van Erp, Theo GM   +2 more
core   +1 more source

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Journal of Neuroinflammation, 2017
Background Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset.
Danny Boerrigter, Thomas W. Weickert, Rhoshel Lenroot, Maryanne O’Donnell, Cherrie Galletly, Dennis Liu, Martin Burgess, Roxanne Cadiz, Isabella Jacomb, Vibeke S. Catts, Stu G. Fillman, Cynthia Shannon Weickert   +11 more
doaj   +1 more source

Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia

Frontiers in Immunology, 2022
Deficit schizophrenia (DS) patient is a homogenous subtype of schizophrenia that includes primary and enduring negative symptoms. This study aimed to compare the differences in cognitive functioning and plasma levels of C-reactive protein (CRP) and ...
Dandan Wang, Yewei Wang, Yan Chen, Lingfang Yu, Zenan Wu, Ruimei Liu, Juanjuan Ren, Xinyu Fang, Chen Zhang   +8 more
doaj   +1 more source

Cognitive control and discourse comprehension in schizophrenia. [PDF]

, 2012
Cognitive deficits across a wide range of domains have been consistently observed in schizophrenia and are linked to poor functional outcome (Green, 1996; Carter, 2006). Language abnormalities are among the most salient and include disorganized speech as
Boudewyn, Megan A, Carter, Cameron S, Swaab, Tamara Y   +2 more
core   +3 more sources

Rethinking Schizophrenia in the Context of Normal Neurodevelopment

Frontiers in Cellular Neuroscience, 2013
The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder.
Vibeke Sorensen Catts, Vibeke Sorensen Catts, Vibeke Sorensen Catts, Samantha Jane Fung, Samantha Jane Fung, Samantha Jane Fung, Leonora Elizabeth Long, Leonora Elizabeth Long, Leonora Elizabeth Long, Dispesh eJoshi, Dispesh eJoshi, Dispesh eJoshi, Ans eVercammen, Ans eVercammen, Ans eVercammen, Ans eVercammen, Katherine Margaret Allen, Katherine Margaret Allen, Katherine Margaret Allen, Stu Gregory Fillman, Stu Gregory Fillman, Stu Gregory Fillman, Loretta eMoore, Debora eRothmond, Debora eRothmond, Duncan eSinclair, Duncan eSinclair, Duncan eSinclair, Yash eTiwari, Yash eTiwari, Yash eTiwari, Shan-Yuan eTsai, Shan-Yuan eTsai, Shan-Yuan eTsai, Thomas Wesley Weickert, Thomas Wesley Weickert, Thomas Wesley Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert   +39 more
doaj   +1 more source

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

Journal of Neuroinflammation, 2020
Background High inflammation status despite an absence of known infection characterizes a subpopulation of people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse neuropathology. Transcripts encoding
Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker, Cynthia Shannon Weickert   +7 more
doaj   +1 more source

Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial

BMC Psychiatry, 2021
Background Cannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized ...
Jesper Østrup Rasmussen, Poul Jennum, Kristian Linnet, Birte Y. Glenthøj, Lone Baandrup   +4 more
doaj   +1 more source

Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]

, 2017
Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC, Feldcamp, LA, Fletcher, PJ, Nobrega, JN, Raymond, R, Wong, AHC   +5 more
core   +1 more source

A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]

, 2012
Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian, Lawford, Bruce, Morris, Phillip, Swagell, Christopher, Voisey, Joanne, Young, Ross   +5 more
core   +2 more sources