Results 21 to 30 of about 620,945 (334)

Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: A support vector machine learning approach

NeuroImage: Clinical, 2014
Heterogeneity in the structural brain abnormalities associated with schizophrenia has made identification of reliable neuroanatomical markers of the disease difficult.
Ian C. Gould, Alana M. Shepherd, Kristin R. Laurens, Murray J. Cairns, Vaughan J. Carr, Melissa J. Green   +5 more
doaj   +1 more source

Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia

Frontiers in Immunology, 2022
Deficit schizophrenia (DS) patient is a homogenous subtype of schizophrenia that includes primary and enduring negative symptoms. This study aimed to compare the differences in cognitive functioning and plasma levels of C-reactive protein (CRP) and ...
Dandan Wang, Yewei Wang, Yan Chen, Lingfang Yu, Zenan Wu, Ruimei Liu, Juanjuan Ren, Xinyu Fang, Chen Zhang   +8 more
doaj   +1 more source

Serotonin and schizophrenia [PDF]

, 2010
Abstract Although the serotonin hypothesis of schizophrenia is one of the oldest neurochemical hypotheses on the pathogenesis of the disease, it is still topical. The concept of how the serotonin system is involved in the origin and progress of schizophrenia has changed considerably over the past decades.
Quednow, Boris B, Geyer, Mark A, Halberstadt, Adam L   +2 more
openaire   +2 more sources

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

Journal of Neuroinflammation, 2020
Background High inflammation status despite an absence of known infection characterizes a subpopulation of people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse neuropathology. Transcripts encoding
Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker, Cynthia Shannon Weickert   +7 more
doaj   +1 more source

Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial

BMC Psychiatry, 2021
Background Cannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized ...
Jesper Østrup Rasmussen, Poul Jennum, Kristian Linnet, Birte Y. Glenthøj, Lone Baandrup   +4 more
doaj   +1 more source

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Journal of Neuroinflammation, 2017
Background Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset.
Danny Boerrigter, Thomas W. Weickert, Rhoshel Lenroot, Maryanne O’Donnell, Cherrie Galletly, Dennis Liu, Martin Burgess, Roxanne Cadiz, Isabella Jacomb, Vibeke S. Catts, Stu G. Fillman, Cynthia Shannon Weickert   +11 more
doaj   +1 more source

Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment

Neuropsychiatric Disease and Treatment, 2020
Schizophrenia is frequently a chronic and disabling disorder, characterized by heterogeneous positive and negative symptom constellations. The objective of this review was to provide information that may be useful for clinicians treating patients with ...
C. Correll, N. Schooler
semanticscholar   +1 more source

Rethinking Schizophrenia in the Context of Normal Neurodevelopment

Frontiers in Cellular Neuroscience, 2013
The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder.
Vibeke Sorensen Catts, Vibeke Sorensen Catts, Vibeke Sorensen Catts, Samantha Jane Fung, Samantha Jane Fung, Samantha Jane Fung, Leonora Elizabeth Long, Leonora Elizabeth Long, Leonora Elizabeth Long, Dispesh eJoshi, Dispesh eJoshi, Dispesh eJoshi, Ans eVercammen, Ans eVercammen, Ans eVercammen, Ans eVercammen, Katherine Margaret Allen, Katherine Margaret Allen, Katherine Margaret Allen, Stu Gregory Fillman, Stu Gregory Fillman, Stu Gregory Fillman, Loretta eMoore, Debora eRothmond, Debora eRothmond, Duncan eSinclair, Duncan eSinclair, Duncan eSinclair, Yash eTiwari, Yash eTiwari, Yash eTiwari, Shan-Yuan eTsai, Shan-Yuan eTsai, Shan-Yuan eTsai, Thomas Wesley Weickert, Thomas Wesley Weickert, Thomas Wesley Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert   +39 more
doaj   +1 more source

Schizophrenia risk from complex variation of complement component 4

Nature, 2016
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia’s strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular ...
Aswin Sekar, Allison R. Bialas, H. de Rivera, Avery Davis, Timothy R. Hammond, Nolan Kamitaki, Katherine Tooley, J. Presumey, M. Baum, Vanessa Van Doren, G. Genovese, Samuel A. Rose, R. Handsaker, M. Daly, M. Carroll, B. Stevens, S. Mccarroll   +16 more
semanticscholar   +1 more source

Schizophrenia [PDF]

Nature Reviews Disease Primers, 2015
Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background that influences early brain development, and is expressed as a combination of psychotic symptoms - such as hallucinations, delusions and disorganization - and motivational and cognitive dysfunctions.
Kahn, René S., Sommer, Iris E., Murray, Robin M., Meyer-Lindenberg, Andreas, Weinberger, Daniel R., Cannon, Tyrone D., O'Donovan, Michael, Correll, Christoph U., Kane, John M., Van Os, Jim, Insel, Thomas R.   +10 more
openaire   +5 more sources