Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]
, 2017 Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC +5 more
core +1 more source
Abnormal Task Modulation of Oscillatory Neural Activity in Schizophrenia
Frontiers in Psychology, 2013 Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response.
Elisa C Dias +6 more
doaj +1 more source
Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
Frontiers in Immunology, 2020 Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson +12 more
doaj +1 more source
Unseen Affective Faces Influence Person Perception Judgments in Schizophrenia. [PDF]
, 2014 To demonstrate the influence of unconscious affective processing on consciously processed information among people with and without schizophrenia, we used a continuous flash suppression (CFS) paradigm to examine whether early and rapid processing of ...
Barrett, Lisa Feldman +2 more
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Novel Schizophrenia Risk Gene TCF4 Influences Verbal Learning and Memory Functioning in Schizophrenia Patients [PDF]
, 2011 Background: Recently, a role of the transcription factor 4 (TCF4) gene in schizophrenia has been reported in a large genome-wide association study. It has been hypothesized that TCF4 affects normal brain development and TCF4 has been related to different
Aleman A +20 more
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Residual negative symptoms differentiate cognitive performance in clinically stable patients with schizophrenia and bipolar disorder [PDF]
, 2014 Cognitive deficits in various domains have been shown in patients with bipolar disorder and schizophrenia. The purpose of the present study was to examine if residual psychopathology explained the difference in cognitive function between clinically ...
Krishnadas, Rajeev +4 more
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Biological Psychiatry Global Open Science, 2023 Background: Findings of reward disturbances in unaffected relatives of patients with schizophrenia suggest reward disturbances as an endophenotype for schizophrenia.
Mette Ødegaard Nielsen +8 more
doaj +1 more source
Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? [PDF]
, 2013 In light of the number of studies conducted to examine the treatment of cognitive impairment associated with schizophrenia (CIAS), we critically reviewed recent CIAS trials.
Buchanan, Robert W +6 more
core
Alterations in functional brain network structure induced by subchronic phencyclidine (PCP) treatment parallel those seen in schizophrenia [PDF]
, 2010 of poster presentation shown at the 2nd Biennial Schizophrenia International Research Conference on Alterations in functional brain network structure induced by subchronic phencyclidine (PCP) treatment parallel those seen in ...
Dawson, Neil +3 more
core +1 more source
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source