Results 21 to 30 of about 260,883 (251)

Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial

BMC Psychiatry, 2021
Background Cannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized ...
Jesper Østrup Rasmussen, Poul Jennum, Kristian Linnet, Birte Y. Glenthøj, Lone Baandrup   +4 more
doaj   +1 more source

Abnormal Task Modulation of Oscillatory Neural Activity in Schizophrenia

Frontiers in Psychology, 2013
Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response.
Elisa C Dias, Stephan eBickel, Michael L Epstein, Pejman eSehatpour, Pejman eSehatpour, Daniel C Javitt, Daniel C Javitt   +6 more
doaj   +1 more source

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology, 2020
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +12 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

From lived experience to leadership: establishing a stakeholder advisory board to guide first-episode psychosis research and services

BMC Health Services Research
Background Advisory boards incorporating people with lived experience (PWLE) with psychosis substantially enhance first-episode psychosis (FEP) services.
B. Priyadharshni, S. Jagadeesan, Krishna Priya, Greeshma Mohan, N. Anerudh, R. Krishnaveni, Vijaya Raghavan   +6 more
doaj   +1 more source

Reward Processing as an Indicator of Vulnerability or Compensatory Resilience in Psychoses? Results From a Twin Study

Biological Psychiatry Global Open Science, 2023
Background: Findings of reward disturbances in unaffected relatives of patients with schizophrenia suggest reward disturbances as an endophenotype for schizophrenia.
Mette Ødegaard Nielsen, Egill Rostrup, Rikke Hilker, Christian Legind, Simon Anhøj, Trevor William Robbins, Barbara J. Sahakian, Birgitte Fagerlund, Birte Glenthøj   +8 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Effectiveness of Virtual - Compensatory Cognitive Training (V-CCT) for improving cognition in persons with schizophrenia - a multi- centre randomized controlled trial

Trials
Background Cognitive deficits are the core component in persons with schizophrenia which impacts their socio-occupational functioning. Also, cognitive deficits cause significant impairment with the person’s quality of life [3].
Sonia Sims, Suvarna Jyothi Kantipudi, Yogitha Ashok, B. Nisha, Subhashini Gopal, Elsa Joseph, S. Amritha, Lakshmi Venkatraman, Pratiksha Venkatasubramanian, Padmavati Ramachandran   +9 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source