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A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia [PDF]
, 2009 We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and 863 controls, following up the top hits in four independent cohorts comprising 1 ...Rujescu, D., Herbert Y Meltzer, Fraser, G., Gennarelli, Massimo, St. Clair, D, JAYATHILAKE K, Rossi Giuseppe, Feng, S, Gennarelli Massimo, Feng, Sheng, Fraser, G, KASPERAVICI, Ge, D., MELTZER HY, Strittmatter, WJ, Fisher, EMC, St Clair, David, RUPPERT A, ROSES AD, Rossi, Giuseppe, Ge Dongliang, Ge, DL, YOON W, NEED AC, David St Clair, RUJESCU D, Sheng Feng, Joseph P McEvoy, Meltzer, Herbert Y, Goldstein, DB, Yoon, Woohyun, St. Clair David, Goldstein, D., Lefkos T Middleton, Meltzer, H., Feng, S., Allen D Roses, Hartmann, Annette M., St Jean, PL, Middleton, Lefkos T., David B Goldstein, Yoon, W, Kasperaviciute, Dalia, Shianna, Kevin V, Moller, HJ, TE D, GOLDSTEIN DB, Kasperavičiūtė, D., Weale, Michael E., Meltzer, HY, FRASER G, Ruppert, A., Middleton, Lefkos T, St Jean, Pamela L, WEALE ME, Shianna, K., Fisher, Elizabeth M. C., Middleton Lefkos T., Heinzen Erin L., Heinzen, E., Crombie Caroline, Ina Giegling, McEvoy, Joseph P, Bonvicini, Cristian, Pamela L St Jean, St. Jean, Pamela L., Keefe, RSE, MÖLLER HJ, Heinzen, EL, Maia, J, Caroline Crombie, Hartmann, A., Need, Anna C, Muglia Pierandrea, Francks, Clyde, St Clair, D, FISHER EM, Dongliang Ge, Giegling Ina, Moeller, H-J, Pierandrea Muglia, Fisher Elizabeth M. C., Goldstein, David B, McEvoy, J., COLA PA, St. Jean Pamela L., Feng Sheng, Cola Philip A., Kasperaviciute, D, Kevin V Shianna, Need Anna C., Weale Michael E., Goldstein, David B., Jessica Maia, Giegling, I., Francks Clyde, Bonvicini, C., Muglia, P., Strittmatter, Warren J., Yoon, W., Ge, Dongliang, McEvoy, JP, Clyde Francks, ROSSI G, Gillian Fraser, Möller, H., Strittmatter, W., MCEVOY JP, St. Clair, D., Ruppert Andreas, Meltzer, Herbert Y., Shianna Kevin V., Fraser, Gillian, Cristian Bonvicini, Roses, Allen D., Gennarelli, M, Warren J Strittmatter, Moeller, Hans-Juergen, Meltzer Herbert Y., Fisher, E., CROMBIE C, Need, AC, Michael E Weale, Ruppert, A, Kasperavičiūtė Dalia, HEINZEN EL, Hartmann, AM, KEEFE RS, Giegling, I, Möller, Hans-Jürgen, Dan Rujescu, Bonvicini Cristian, Goldstein David B., ST CLAIR D, Need, A., Erin L Heinzen, Annette M Hartmann, Heinzen, Erin L, Francks, C, Elizabeth M C Fisher, Gennarelli, M., Muglia, Pierandrea, MIDDLETON LT, Richard S E Keefe, HARTMANN AM, Shianna, KV, Rujescu, Dan, McEvoy Joseph P., Crombie, C., Crombie, Caroline, Strittmatter, Warren J, Woohyun Yoon, Rujescu Dan, St. Jean, P., Ge, D, Karu Jayathilake, McEvoy, Joseph P., Cola, Philip A., Keefe, Richard S E, Jayathilake Karu, Anna C Need, Jayathilake, K., Giegling, Ina, FENG S, Yoon Woohyun, Middleton, LT, Heinzen, Erin L., Roses, Allen D, Cola, PA, Cola, Philip A, St. Clair, David, GE D, Andreas Ruppert, Strittmatter Warren J., Bonvicini, C, St. Jean, PL, Weale, M., Shianna, Kevin V., Cola, P., Rujescu, D, Philip A Cola, Giuseppe Rossi, Middleton, L., Möller Hans-Jürgen, Jayathilake, K, Weale, ME, Jayathilake, Karu, Roses, AD, FRANCKS C, MAIA J, Hartmann, Annette M, Keefe, R., Rossi, G., Roses Allen D., Muglia, P, ST JEAN PL, Roses, A., Fisher, Elizabeth M C, BONVICINI C, Ruppert, Andreas, Maia, Jessica, Massimo Gennarelli, Maia Jessica, GIEGLING I, Francks, C., Keefe Richard S. E., SHIANNA KV, Maia, J., MUGLIA P, Rossi, G, Dalia Kasperaviciūte, Fraser Gillian, Crombie, C, Weale, Michael E, Hartmann Annette M., Need, Anna C., Keefe, Richard S. E., Hans-Jürgen Möller, STRITTMATTER WJ +218 morecore +1 more sourceSchizophrenia
The Lancet, 2022 Schizophrenia, characterised by psychotic symptoms and in many cases social and occupational decline, remains an aetiological and therapeutic challenge. Contrary to popular belief, the disorder is modestly more common in men than in women. Nor is the outcome uniformly poor.Jauhar, Sameer, Johnstone, Mandy, McKenna, Peter J +2 moreopenaire +3 more sourcesLocal and global limits on visual processing in schizophrenia. [PDF]
, 2015 Schizophrenia has been linked to impaired performance on a range of visual processing tasks (e.g. detection of coherent motion and contour detection).Steven C. Dakin, Bobin, Tracy; id_orcid, Anderson, EJ, Patricia Carlin, Carlin Patricia, Elaine J Anderson, Steven C. Dakin (400934), Marc S Tibber, Tibber, Marc S., Anderson, Elaine J., Shergill, SS, Tracy Bobin, Carlin, P, Dakin, Steven C., Tibber Marc S., Dakin, SC, Tracy Bobin (400932), Elaine J. Anderson, Sukhwinder S Shergill, Steven C Dakin, Marc S. Tibber, Tibber, MS, Elaine J. Anderson (374473), Shergill Sukhwinder S., Bobin Tracy, Marc S. Tibber (374472), Sukhwinder S. Shergill (320100), Anderson Elaine J., Bobin, T, Sukhwinder S. Shergill, Dakin Steven C., Patricia Carlin (400933), Carlin, Patricia, Shergill, Sukhwinder S. +33 morecore +1 more sourceRethinking Schizophrenia in the Context of Normal Neurodevelopment
Frontiers in Cellular Neuroscience, 2013 The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder.Vibeke Sorensen Catts, Vibeke Sorensen Catts, Vibeke Sorensen Catts, Samantha Jane Fung, Samantha Jane Fung, Samantha Jane Fung, Leonora Elizabeth Long, Leonora Elizabeth Long, Leonora Elizabeth Long, Dispesh eJoshi, Dispesh eJoshi, Dispesh eJoshi, Ans eVercammen, Ans eVercammen, Ans eVercammen, Ans eVercammen, Katherine Margaret Allen, Katherine Margaret Allen, Katherine Margaret Allen, Stu Gregory Fillman, Stu Gregory Fillman, Stu Gregory Fillman, Loretta eMoore, Debora eRothmond, Debora eRothmond, Duncan eSinclair, Duncan eSinclair, Duncan eSinclair, Yash eTiwari, Yash eTiwari, Yash eTiwari, Shan-Yuan eTsai, Shan-Yuan eTsai, Shan-Yuan eTsai, Thomas Wesley Weickert, Thomas Wesley Weickert, Thomas Wesley Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert +39 moredoaj +1 more sourceNuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines
Journal of Neuroinflammation, 2020 Background High inflammation status despite an absence of known infection characterizes a subpopulation of people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse neuropathology. Transcripts encoding Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker, Cynthia Shannon Weickert +7 moredoaj +1 more sourceIncreased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
Frontiers in Immunology, 2020 Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert +12 moredoaj +1 more sourceFamily-based association study of SELENBP1 in schizophrenia
, 2009 The SELENBP1 gene previously was found to be up-regulated in microarray analysis of both peripheral blood cell and brain tissue samples from schizophrenia patients Quantitative PCR analysis subsequently corroborated the altered expression of SELENBP1 in ...Kanazawa, Tetsufumi; Glatt, Stephen J.; Faraone, Stephen V.; Hwu, Hai-Gwo; Yoneda, Hiroshi; Tsuang, Ming T., 胡海國;莊明哲 +1 morecore +1 more source