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Schizophrenia [PDF]

The Lancet, 2016
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement ...
Michael J Owen, Akira Sawa, Preben B Mortensen   +2 more
openaire   +8 more sources

Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders [PDF]

, 2016
Neurological soft signs (NSSs) bear the promise for early detection of schizophrenia spectrum disorders. Nonetheless, the sensitivity and specificity of NSSs in the psychosis continuum remains a topic of controversy.
Yu, Xin, Chan, Raymond C. K., Wang, Chuan-yue, Rosenthal, Robert, Wang, Ya, Chan, Raymond C.K., Lui, Simon SY, Cheung, Eric F.C., Geng, Fu Lei, Wang, Chuan Yue, Xie, Weizhen, Geng, Fu-lei, Cheung, Eric F. C., Chan, Raymond CK, Cheung, Eric FC, Lui, Simon S. Y., Lui, Simon S.Y.   +16 more
core   +1 more source

Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia

Journal of Neuroinflammation, 2022
Background There is growing evidence that neuroinflammation may contribute to schizophrenia neuropathology. Elevated pro-inflammatory cytokines are evident in the midbrain from schizophrenia subjects, findings that are driven by a subgroup of patients ...
A. Petty, L. J. Glass, D. A. Rothmond, T. Purves-Tyson, A. Sweeney, Y. Kondo, S. Kubo, M. Matsumoto, C. Shannon Weickert   +8 more
doaj   +1 more source

Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: A support vector machine learning approach

NeuroImage: Clinical, 2014
Heterogeneity in the structural brain abnormalities associated with schizophrenia has made identification of reliable neuroanatomical markers of the disease difficult.
Ian C. Gould, Alana M. Shepherd, Kristin R. Laurens, Murray J. Cairns, Vaughan J. Carr, Melissa J. Green   +5 more
doaj   +1 more source

Novel Schizophrenia Risk Gene TCF4 Influences Verbal Learning and Memory Functioning in Schizophrenia Patients [PDF]

, 2011
Background: Recently, a role of the transcription factor 4 (TCF4) gene in schizophrenia has been reported in a large genome-wide association study. It has been hypothesized that TCF4 affects normal brain development and TCF4 has been related to different
Lennertz, Leonhard, Wölwer, Wolfgang, Leonhard Lennertz, Gaebel, Wolfgang, Häfner, Heinz, Möller, Hans-Jürgen, Maier, Wolfgang, Heinz Häfner, Michael Wagner, Dan Rujescu, Svenja Schulze-Rauschenbach, Anna Schuhmacher, Wagner, Michael, Petra Franke, Ingo Frommann, Wolfgang Gaebel, Wolfgang Maier, Schulze-Rauschenbach, Svenja, Rainald Mössner, Schuhmacher, Anna, Wolfgang Wölwer, Martin W. Landsberg, Landsberg, Martin W., Hans-Jürgen Möller, Franke, Petra, Mössner, Rainald, Rujescu, Dan, Frommann, Ingo   +27 more
core   +1 more source

Schizophrenia

New England Journal of Medicine, 2020
The lifetime prevalence of schizophrenia is 1%. Schizophrenia is among the most severe mental illnesses and gives rise to the highest treatment costs per patient of any disease. It is characterized by frequent relapses, marked impairment of quality of life, and reduced social and work participation.The group entrusted with the creation of the German ...
Matthew L, Goldman, Harold A, Pincus, Christina, Mangurian   +2 more
openaire   +6 more sources

Cost of treatment in schizophrenia in six European countries [PDF]

, 2009
Background and aims: As part of an RCT in six European sites, the direct mental health care cost for 422 patients with schizophrenia was analysed according to how total and medication costs differed across sites and which variables were likely to predict
McCabe, R, Bullenkamp, J, Rössler, W, Torres-Gonzalez, F, Hansson, Lars, Lauber, Christoph, Martinez-Leal, Rafael, Salize, H, Durk Wiersma, Torres-Gonzales, F, Priebe, Stefan, McCabe, R., Martinez-Leal, R., Svensson, Bengt, McCabe, Rosemarie, Rosemarie McCabe, Hansson, Lars,, Hansson, L., van den Brink, R., Lars Hansson, Salize, HJ, Lauber, C., van den Brink, Rob, Martinez-Leal, R, Rafael Martinez-Leal, Hans Joachim Salize, Lauber, C, Priebe, S, Lund University., Salize, H.J., Wiersma, Durk, Torres-Gonzalez, Francisco, Reinhard, I, Iris Reinhard, Wiersma, D, Priebe, S., Christoph Lauber, Svensson, B., Wiersma, D., Svensson, Bengt,, Rob van den Brink, Roessler, Wulf, Reinhard, Iris, Jens Bullenkamp, Bullenkamp, J., Stefan Priebe, Francisco Torres-Gonzalez, Reinhard, I., Bullenkamp, Jens, Hansson, L, van den Brink, R, Wulf Rössler, Salize, Hans Joachim, Rossler, W., Svensson, B, Torres-Gonzalez, F., Bengt Svensson   +56 more
core   +1 more source

Habitual prospective memory in schizophrenia [PDF]

, 2003
Background Prospective memory (PM), the act of remembering that something has to be done in the future without any explicit prompting to recall, provides a useful framework with which to examine problems in internal-source monitoring. This is because it
Gilbert Abigail L, Elvevåg, Brita, Elvevåg Brita, Brita Elvevåg, Maylor, Elizabeth A., Elizabeth A Maylor, Abigail L Gilbert, Maylor Elizabeth A, Gilbert, Abigail l.   +8 more
core   +1 more source

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Journal of Neuroinflammation, 2017
Background Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset.
Danny Boerrigter, Thomas W. Weickert, Rhoshel Lenroot, Maryanne O’Donnell, Cherrie Galletly, Dennis Liu, Martin Burgess, Roxanne Cadiz, Isabella Jacomb, Vibeke S. Catts, Stu G. Fillman, Cynthia Shannon Weickert   +11 more
doaj   +1 more source

A nation-wide twin study of social cognition in schizophrenia spectrum disorders

npj Schizophrenia, 2022
We examined social cognition in 32 monozygotic (MZ) and 21 dizygotic (DZ) twin pairs concordant or discordant for a schizophrenia spectrum diagnosis and healthy control (HC) twin pairs (29 MZ/20 DZ).
Cecilie K. Lemvigh, Birte Y. Glenthøj, Birgitte Fagerlund   +2 more
doaj   +1 more source