Results 41 to 50 of about 33,254 (223)

Synthetic biology approaches to generate temperature‐sensitive alleles for the Sterile Insect Technique

Insect Science, EarlyView.
Abstract The Sterile Insect Technique (SIT) is an environmentally friendly, sustainable pest control approach, which uses large‐scale releases of sterile insects to suppress or eradicate target populations through infertile matings. The efficiency of SIT is enhanced by male‐only releases requiring genetic sexing strains (GSSs) that are classically ...
Chun Yin Leung, Ernst A. Wimmer, Hassan M. M. Ahmed   +2 more
wiley   +1 more source

Nedd8 processing enzymes in Schizosaccharomyces pombe [PDF]

BMC Biochemistry, 2013
Abstract Background Conjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell cycle regulators.
O'Donoghue, Jean, Bech-Otschir, Dawadschargal, Larsen, Ida, Wallace, Mairi, Hartmann-Petersen, Rasmus, Gordon, Colin   +5 more
openaire   +5 more sources

Explaining lengths and shapes of yeast by scaling arguments. [PDF]

PLoS ONE, 2009
Lengths and shapes are approached in different ways in different fields: they serve as a read-out for classifying genes or proteins in cell biology whereas they result from scaling arguments in condensed matter physics.
Daniel Riveline
doaj   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2012
The ERH gene encodes a highly conserved small nuclear protein with a unique amino acid sequence and three-dimensional structure but unknown function. The gene is present in animals, plants, and protists but to date has only been found in few fungi.
Marek K Krzyzanowski, Ewa Kozlowska, Piotr Kozlowski   +2 more
doaj   +1 more source

Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity

The FEBS Journal, EarlyView.
A novel assay evaluates plant biostimulants targeting the brassinosteroid receptor BRI1, a central component in plant growth and development. By expressing BRI1 in fission yeast, functional activation by brassinolide (BL) was enabled. Transcriptomic profiling identified BL‐responsive genes, leading to a GFP‐based reporter system. This platform offers a
Maribel Marquina, Montserrat Ricart‐Fort, Rocío Díaz‐Parra, Sandra López‐Avilés, Tula Yance, Pablo Quirós, Elena Contreras, Ignasi Salaet, Sergio Atares, Rosa Aligué   +9 more
wiley   +1 more source

Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

Nature Communications, 2019
An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential ...
Jun Li, Hai-Tao Wang, Wei-Tao Wang, Xiao-Ran Zhang, Fang Suo, Jing-Yi Ren, Ying Bi, Ying-Xi Xue, Wen Hu, Meng-Qiu Dong, Li-Lin Du   +10 more
doaj   +1 more source

HIV-1 Protease in the Fission Yeast Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2016
BACKGROUND:HIV-1 protease (PR) is an essential viral enzyme. Its primary function is to proteolyze the viral Gag-Pol polyprotein for production of viral enzymes and structural proteins and for maturation of infectious viral particles. Increasing evidence
Zsigmond Benko, Robert T Elder, Ge Li, Dong Liang, Richard Y Zhao   +4 more
doaj   +1 more source

CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection

Nature Communications, 2016
The repair of double-strand DNA breaks by homologous recombination requires resection of the DNA ends. Here the authors show that in Schizosaccharomyces pombe and human cells, Wdr70 is recruited as part of the CRL4 complex to promote ubiquitination of ...
Ming Zeng, Laifeng Ren, Ken'Ichi Mizuno, Konstantinos Nestoras, Haibin Wang, Zizhi Tang, Liandi Guo, Daochun Kong, Qiwen Hu, Qun He, Lilin Du, Antony M. Carr, Cong Liu   +12 more
doaj   +1 more source

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source