Results 21 to 30 of about 19,796 (265)

A Design Methodology for Exploring and Communicating System Values and Assumptions

Journal of the Text Encoding Initiative, 2014
This paper attempts to make two contributions to discussions related to TEI: (1) an analysis of how tools used for working with TEI documents encourage certain values and make certain assumptions about the work of textual editing and (2) a report on a ...
Daniel Carter
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Modeling genetic networks. Gustave Roud's œuvre, from diary to poetry collections

Umanistica Digitale, 2019
This paper pursues the analysis, modelling and representation of the relationships between the different entities concerned by genetic criticism (documents and publications), in the context of a scholarly digital edition.Our cases study are taken from ...
Alessio Christen, Elena Spadini
doaj   +1 more source

Scholarly Editing and AI: Machine Predicted Text and Herculaneum Papyri

magazén, 2021
In 2016 the Digital Restoration Initiative (DRI) at the University of Kentucky, under the direction of Professor Brent Seales, virtually unrolled a carbonized parchment scroll from Ein Gedi, revealing a copy of Leviticus written in iron gall ink.
Brusuelas, James H.
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Visualising the Catalogues of Digital Editions

Journal of Electronic Publishing
This article provides a data-driven overview of the developments in the field of digital scholarly editing. It surveys and evaluates the available data source on digital scholarly editions and provides longitudinal analysis of changes in number of ...
Bridgette Wessels, James O'Sullivan, Michael Kurzmeier, Mike Pidd, Orla Murphy   +4 more
doaj   +2 more sources

Biomedical Scholarly Article Editing and Sharing using Holistic Semantic Uplifting Approach

Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022
Efficient practices to provide access to biomedical publications facilitate the timely transfer of information from the scientific research community to peer investigators and other healthcare practitioners. At present, the portable document format (PDF)
Asim Abbas, Steve Fonin Mbouadeu, Fazel Keshtkar, Joan DeBello, Syed Ahmad Chan Bukhari   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source