Results 51 to 60 of about 4,001 (290)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Sententiae, 2018 The article analyses the explication of the infinity in the philosophical courses taught at Kyiv-Mohyla Academy at the 17th and 18th centuries. It examines 12 philosophical courses – since 1645 (the course by Inokentii Gizel) until 1751 (the course by ...
Mykola Symchych
doaj +1 more source
Thomas J. Blakeley, Soviet Scholasticism
, 1965 Vander Gucht Robert. Thomas J. Blakeley, Soviet Scholasticism . In: Revue Philosophique de Louvain. Troisième série, tome 63, n°77, 1965.
Vander Gucht, Robert
core +1 more source
Man as Image of Nature in Magnus Hundt: The Perspective of a Thomist ca. 1500
Histories, 2023 This paper draws on a late medieval example to show that images of nature can also be images of the human body. It presents the Anthropologium de hominis dignitate by the Leipzig magister Magnus Hundt (1449–1519).
Karsten Engel
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Blackfriars, 1921 The two words Art and Scholasticism, set down thus side by side, look at first sight somewhat oddly paired. A little book with this title, which is useful out of all proportion to its size, shows that Scholastic philosophy offers a very sound and far-reaching theory of art, and for anyone interested in such questions will well repay careful reading ...
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Rosmini, la Seconda Scolastica e i grandi temi del giusnaturalismo moderno
Rosmini StudiesThe essay explores the influence of Second Scholasticism legal theories on Rosmini’s Filosofia del diritto. After verifying which authors Rosmini mentions and counting the number of citations, the paper examines the importance that Rosmini attributes to
Franco Todescan
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source