Results 71 to 80 of about 1,101,051 (314)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
A Study on the Shear Wall Ratio in School Buildings
Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü, 2019 Within this current study, in order to be safe of school buildings against an earthquake, shear wall ratio, must have been a plan, was determined depending on floor type.
Hakan ULUTAŞ +3 more
doaj +1 more source
Earthquake Science Explained [PDF]
This booklet features a collection of articles originally published for teachers by the San Francisco Chronicle. It presents some of the new understanding gained and scientific advances made in the century since the Great 1906 San Francisco Earthquake ...
core +1 more source
Seismic retrofitting and health monitoring of school buildings of Cyprus [PDF]
, 2013 The vulnerability of existing buildings to seismic forces and their retrofitting is an international problem. The majority of structures in seismic-prone areas worldwide are structures that have been designed either without the consideration of seismic ...
Chrysostomou, C. Z. +5 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A simple, space constrained NIRIM type reactor for chemical vapour deposition of diamond
AIP Advances, 2018 In this paper the design of a simple, space constrained chemical vapour deposition reactor for diamond growth is detailed. Based on the design by NIRIM, the reactor is composed of a quartz discharge tube placed within a 2.45 GHz waveguide to create the ...
Evan L. H. Thomas +4 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
High Performance School Buildings: Energy-Smart Schools That Make a Difference [PDF]
, 2001 Over seventy percent of U.S. schools still in use today were built before 1960, according to the General Accounting Office. In the next decade, school districts around the nation will have to replace or renovate over six thousand of these buildings, and ...
Susan Ziff
core