Results 71 to 80 of about 101,661 (312)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Gladstone, improve public school buildings and grounds

open access: yes, 1938
Specific individuals mentioned: Ray Gress, J.C. Neurohr, Peter KollingAdministrative documents relating to Works Projects Administration project to?
United States. Works Projects Administration.
core  

Refurbishment and school buildings management in a smart building environment

open access: yesAIP Conference Proceedings, 2018
Building Information Modelling is a methodology, which is able to take into account many data, both geometrical and non-geometrical, in order to evaluate at the actual condition of the asset. The project has the scope of evaluating the conditions of different school buildings, in order to develop a way to choose the best-tailored management solution to
Di Giuda, Giuseppe Martino   +5 more
openaire   +4 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

U.S. Naval School, General Line, Monterey Calif.

open access: yes, 1948
A scrapbook of photographic images of the General Life School buildings, architectural features, locations and ...
Naval Postgraduate School (U.S.)
core  

Energy Compensation Model between a Net Zero Energy Building and a School Building

open access: yes, 2023
In the European Union, the concept of Net Zero Energy Building (NZEB) has been known for many years, defined as a building with a remarkably high energy performance whose yearly needs are totally compensated by renewable energy sources.
Ilaria Ciriello   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Regulations and robust low-carbon buildings

open access: yes, 2009
Building regulations and associated calculation methods have been rapidly evolving, driven in Europe by the European Union Energy Performance of Buildings Directive. As an example, the current UK regulations are explored in relation to buildings that are
Tuohy, Paul
core   +1 more source

A Methodology for Integrated Refurbishment Actions in School Buildings

open access: yesBuildings, 2018
Educational buildings could play leading roles in increasing high-performance building refurbishments across Europe. The city of Vienna has substantially modernized its schools in the last decade, however mostly single refurbishment measures have been ...
Doris Österreicher
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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