Results 81 to 90 of about 101,661 (312)

Solution sets for zero emission / zero energy school buildings

, 2022
One of the purposes of the School of the Future project is to provide designers and planners with retrofit guidelines for concepts and technologies regarding energy efficiency and good indoor environment quality in school buildings - from simple, but ...
Erhorn-Kluttig, Heike, Erhorn, Hans
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Investigation on Summer Thermal Comfort and Passive Thermal Improvements in Naturally Ventilated Nepalese School Buildings

, 2023
Students require a comfortable thermal environment for better academic learning and health in general. In Nepal, the majority of school buildings are constructed using local materials, but little consideration is provided to the thermal environment ...
Hom Bahadur Rijal, Mishan Shrestha
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Modernising Secondary School Buildings in Portugal [PDF]

The quality of school buildings is critically important in the drive for improving education. Good quality facilities provide teachers and students with supportive environments which are responsive to their changing needs and can make a real difference ...
Blyth, A., Gorey, A., Almeida, R., Hostens, G., Forrester, D.   +4 more
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Head, Postgraduate Department / Superintendent, Postgraduate School [PDF]

, 1958
Appendix B, Exerpted from “Brief history prepared at the time of the dedication of new Engineering School buildings, Monterey ...

core  

BUILDING CONDITION ASSESSMENT FOR SCHOOL BUILDING

PLANNING MALAYSIA
This research explores the multifaceted domain of Building Maintenance Management (BMM), focusing on issues, challenges, and assessment methodologies. A comprehensive review of literature spanning various academic disciplines and professional fields was conducted to synthesize existing knowledge and identify gaps in understanding.
Siti Fatimah Azzahra Mohd Nazri, Khairusy Syakirin Has-Yun Hashim, Mohamad Saiful Nizam Mohd Suhaimi   +2 more
openaire   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Development of an adaptive window-opening algorithm to predict the thermal comfort, energy use and overheating in buildings

, 2008
This investigation of the window opening data from extensive field surveys in UK office buildings demonstrates: 1) how people control the indoor environment by opening windows; 2) the cooling potential of opening windows; and 3) the use of an ‘adaptive ...
Clarke, Joseph Andrew, Tuohy, Paul Gerard, Humphreys, Michael A., Nicol, J. Fergus, Tuohy, P., Clarke, J., Rijal, H. B., Rijal, Hom B., Samuel, Aizaz, Humphreys, M. A., Samuel, A., Nicol, F.   +11 more
core   +1 more source