Results 91 to 100 of about 4,049,211 (314)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Organizational culture and climate survey: development and evaluation model for an elementary school [PDF]
, 2008 Includes bibliographical ...
Mertzig, Heidi K.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
INCORPORATING LOCAL WISDOM INTO ENGLISH LANGUAGE TEACHING (ELT) [PDF]
, 2013 Since language (e.g.local languages)is an important part of a culture, it should be maintained and revitalized. When the language undergoes attrition because of global culture, many aspects in culture will also be extinct.
Suharno, Suharno
core
Literacy assessment practices: Moving from standardised to ecologically valid assessments in secondary schools [PDF]
, 2007 SSLI test protocol data revealed the dominance of 'central' literacy measures and 'local' subject-specific measures aligned to institutional requirements, curriculum and national examination content.
Whitehead, David
core +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The school sport co-ordinator programme: evaluation of phases 1 and 2 2001–2003 [PDF]
, 2003 This report evaluates the effect of the School Sport Co-ordinator programme (the programme) since its introduction in autumn 2000. The programme is part of the national physical education (PE), School Sport and Club Links strategy led by the Department ...
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Retracted: Cross-Media Narrative and Emotional Identity Mechanism of School Culture in Media Integration Environment. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source