Results 61 to 70 of about 968,288 (254)

School health services in Enugu East, Nigeria: perspectives from a resourcepoor setting

Healthcare in Low-resource Settings, 2017
School health services (SHS) have widespread impact on the health of a large number of children with implications on access to primary health care especially in developing countries.
Adaobi I. Bisi-Onyemaechi, Afonne N. Akani, Anthony N. Ikefuna, Beckie N. Tagbo, Josephat M. Chinawa, Ugo N. Chikani   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PRACTICAL PROCEDURES IN SCHOOL HEALTH SERVICE*,†

Journal of School Health, 1938
HOW does an executive of any organization, public or private, find out whether his department is doing an effective job? This is a practical inquiry. Complacency and self-congratulation have little place in modern administrative jobs. The administrator must know to what degree he is successfully reaching his objectives.
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evaluation of School Health Services in Public Primary Schools in Bonny Local Government Area, Rivers State

Nigerian Journal of Paediatrics
Background: Effectivee school health services will not only address ill health among school children but will also reduce absenteeism and drop out rates, thereby encouraging completion of schooling, Objective: To evaluate the school health services ...
Alex-Hart BA,, Akani NA, Nkangieme EFO
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Kicking the can down the road? Referral services and a school-based primary healthcare service for rural primary school children

Rural and Remote Health
Introduction: Several new school-located nurse models have recently been established in Australia. These services aim to improve health and education outcomes for children in less advantaged communities; however, data describing their activities and ...
Catherine Sanford, David Lyle, Sarah Dennis, Danielle White, Karen Harding-Smith, Armando Teixeira-Pinto, Rebecca Smith, Robert Dyson, Emily Saurman   +8 more
doaj   +1 more source

Inequity in awareness and utilization of adolescent reproductive and sexual health services in union territory, Chandigarh, North India

Indian Journal of Public Health, 2015
Background: Adolescents are a heterogeneous, vulnerable, and sexually active group. Geographical and educational health disparities exist among urban, rural, and slum adolescents and among out-of-school and school-going adolescents, respectively ...
Madhu Gupta, Nidhi Bhatnagar, Pankaj Bahugana   +2 more
doaj   +1 more source