Results 71 to 80 of about 274,012 (313)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The Impact of High Stakes Testing on School Leadership
School Leadership Review, 2015 As I observed and recorded a classroom teacher at the beginning of the spring semester, I remembered how much I enjoyed working with teachers to help them grow and become master teachers.
Yanira Oliveras-Ortiz
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Reimagining ethical leadership as relational, contextual, and political [PDF]
, 2014 Although existing theories have made considerable achievements in highlighting the crucial connection between ethics and leadership, this paper proposes three key limitations of the field: an overwhelming focus on the individual at the expense of the ...
Helena Liu
core
Group coaching: a new way of constructing leadership identity? [PDF]
, 2015 This paper focuses on group coaching, one of the newer school leadership development approaches to recently emerge. Using a group-coaching methodology developed at the University of Oslo, we deconstruct the concept of leadership identity as it is ...
Aas, Marit, Vavik, Mette
core +1 more source
School Leadership Review, 2014 One of the most important and influential persons in the governance structure of the local school district is the Superintendent of Schools. Functioning as the CEO of the district, the superintendent is responsible for a myriad of functions.
Greg Weiss +3 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Nine lessons of successful school leadership teams : distilling a decade of innovation [PDF]
, 2003 Nine Lessons of Successful School Leadership Teams is both a practical, on-the-ground resource and a valuable perspective on how school leadership teams can make a difference in student achievement.viii, 114 p.: ill.; 21 ...
Bill McKeever +1 more
core
Maintaining the Human Touch in Educational Leadership
School Leadership Review, 2012 It is a pleasure to be invited to contribute to this special edition of the TCPEA School Leadership Review. TCPEA has been a valuable organization for me as the relationships that have been fostered through it have enabled me to grow personally and ...
Sandra Harris
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source