Results 221 to 230 of about 868,708 (295)

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

A dataset of paired blood mRNA and microRNA sequencing across acute septic shock and recovery. [PDF]

Sci Data
Molnár K, Maricza K, Elek Z, Kovács-Nagy R, Fóthi Á, Bánlaki Z, Losoncz E, Húri B, Kádas J, Keszler G, Rónai Z.   +10 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Chromosome-level genome assembly and annotation of the tropical sea cucumber Holothuria fuscocinerea. [PDF]

Sci Data
Wang X, Huang Q, Qin Z, Fan D, Ren C, Pan W, Huang J, Zhang Z, Ge H, Liang J, Xu J, Zhang Y, Luo P, Jiang X, Sun L, Sun H, Hu C, Yan A, Chen T.   +18 more
europepmc   +1 more source

Open Source Software in School Libraries [PDF]

, 2006
Johnson, Larry, Lamb, Annette
core  

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Genomes of enteric pathogen isolates from polymicrobial infections in cases of pediatric diarrhea. [PDF]

Microbiol Resour Announc
Hritzo BA, Michalski Wilhelm JM, Rasko DA.   +2 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Complete genomes of hybrid <i>Escherichia coli</i> isolates containing virulence factors from enterotoxigenic and enteropathogenic pathovars. [PDF]

Microbiol Resour Announc
Hritzo BA, Michalski JM, Sikorski MJ, Rasko DA.   +3 more
europepmc   +1 more source