Results 51 to 60 of about 868,708 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

School libraries Pathfinders

open access: yesIranian Journal of Information Processing & Management, 2009
School library represents one of the important locations suited for offering reference services. The skill set necessary in order to use information resources, is called information literacy. When discussing information literacy and means of enhancing it,
Shideh Taleban
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

The Problem of Reading Habits of Children and The Youth: An Assessment of the Functionality of School Libraries

open access: yesTürk Kütüphaneciliği, 2017
Education is a process that begins in the family and supported by different institutions in the progressive stages. One of the most important of these institutions is school libraries.
İsmail Akman, Nuran Akman
doaj  

School libraries, political information and information literacy provision : findings from a Scottish study [PDF]

open access: yes, 2016
This paper presents the findings of research which explored Scottish school libraries’ information provision and information literacy support in the run-up to two major political events: the 2014 Scottish Independence Referendum (SIR) and the 2015 ...
Smith, Lauren N.
core   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Information needs and constraints of access to educational information in the Fort Beaufort Education District

open access: yesSouth African Journal of Education, 2019
Types of educational information needed by learners, their level of access and librarians’ supportive roles in learning are pertinent to the attainment of quality education. This study seeks to identify the types of educational information needed by high
Stella O. Oyediran-Tidings   +2 more
doaj   +1 more source

Role clarification and role dilemmas: New challenges for teacher-librarians? [PDF]

open access: yes, 2001
The role of the teacher-librarian has been increasingly clarified by national and provincial school library associations. Successful teacher-librarian. that is.
Haycock, Ken
core   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Law Libraries and Laboratories: The Legacies of Langdell and His Metaphor [PDF]

open access: yes, 2014
Law Librarians and others have often referred to Harvard Law School Dean C.C. Langdell’s statements that the law library is the lawyer’s laboratory.
A Bobrie   +24 more
core   +7 more sources

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