Results 91 to 100 of about 2,681,391 (306)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Maltese primary school principalship: Perceptions, roles and responsibilities
, 1995 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The main aim of this research was to investigate the conditions that influence and shape the occupational perceptions of principals; systematically observe ...
Bezzina, Christopher George +1 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Student Life E-Newsletter December 12, 2016
, 2016 https://digitalcommons.law.seattleu.edu/studentlife/1016/thumbnail ...
Student Life, Seattle University School of Law
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Student Life E-Newsletter September 09, 2019
, 2019 https://digitalcommons.law.seattleu.edu/studentlife/1053/thumbnail ...
Student Life, Seattle University School of Law
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Student Life E-Newsletter February 16, 2021
, 2021 https://digitalcommons.law.seattleu.edu/studentlife/1078/thumbnail ...
Student Life, Seattle University School of Law
core
The Effect of Exercise on School Life Satisfaction in Korean Children and Adolescents Considering the Mediation Effects of Physical Health Awareness, Self-Esteem, and Depression. [PDF]
Iran J Public Health, 2023 Bae MH.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source