Results 121 to 130 of about 7,388,711 (304)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

School Everyday Life in Images

Educação & Realidade, 2017
This article aims at questioning school everyday life in images, based on intercessors and concepts from Deleuze and Guattari’s Philosophy of Difference.
Carlos Eduardo Ferraço, Marco Antonio Oliva Gomes   +1 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Introduction: Espaces scolaires et projets éducatifs

Revue Internationale d’Éducation de Sèvres, 2013
Maurice Mazalto, Luca Paltrinieri
doaj   +1 more source

MENSTRUATION DURING SCHOOL LIFE [PDF]

BMJ, 1920
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Le temps, une ressource pédagogique à préserver : une analyse dans dix pays d’Afrique subsaharienne

Revue Internationale d’Éducation de Sèvres, 2021
Rosa Mahdjoub
doaj   +1 more source

STRATEGIES TO GENERATE SCHOOL LIFE

Ra Ximhai, 2015
This article aims to provide the school community the necessary tools to promote in students of Secondary Education coexistence, communication skills and non-violent resolution of conflicts. The methodology used in the construction of this paper focused
David Gutiérrez-Méndez, Eduardo Pérez-Archundia   +1 more
doaj  

Life satisfaction and school experience in adolescence: the impact of school supportiveness, peer belonging and the role of academic self-efficacy and victimization

Cogent Education
Several factors influence adolescents’ life satisfaction. At school, peer relatedness and school supportiveness, as well as individual self-perceptions such as academic self-efficacy, promote life satisfaction.
Luciana Castelli, Jenny Marcionetti
doaj   +1 more source