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Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Carrie Humble MBE rues the days when falling off was an acceptable part of learning to ride
openaire +3 more sources
Soybean genotypes show diverse physiological responses to drought, but specific physiological traits that can be used to evaluate drought tolerance have not been identified.
Md Mokter Hossain +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Student Life E-Newsletter April 25, 2022
https://digitalcommons.law.seattleu.edu/studentlife/1100/thumbnail ...
Student Life, Seattle University School of Law
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Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Student Life E-Newsletter April 05, 2021
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Student Life, Seattle University School of Law
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Rural school children picturing family life
Rurality is an active agent and central to the lived experiences of children growing up on a farm and attending a farm school. It is a key to their everyday experiences, and influences family life, schooling and their future.
Naydene de Lange +3 more
doaj +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Student Life E-Newsletter January 31, 2022
https://digitalcommons.law.seattleu.edu/studentlife/1089/thumbnail ...
Student Life, Seattle University School of Law
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