Results 111 to 120 of about 1,177,528 (315)
The Prescription Opioid Epidemic: an Evidence-Based Approach [PDF]
, 2015 A group of experts, led by researchers at the Johns Hopkins Bloomberg School of Public Health, issued this report aimed at stemming the prescription opioid epidemic, a crisis that kills an average of 44 people a day in the U.S.
G. Caleb Alexander, Shannon Frattaroli
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
La vidéo interactive, une voie de développement pour l’activité des personnels de direction
ActivitésManagers are tasked with organising the work of their staff while at the same time ensuring their quality of life in the workplace. Tensions between these two objectives can nevertheless occur, as experienced by a high school principal when, for personal
Hélène Veyrac
doaj +1 more source
Avoiding Accountability: How Charter Operators Evade Ohio's Automatic Closure Law [PDF]
, 2013 Ohio's charter-closure law is touted as one of the toughest in the nation because it requires the automatic closure of charter schools that consistently fail to meet academic standards.
Jennifer DePaoli, Piet van Lier
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Managers' Self-efficiency and Its Effect on Exhaustion at the Public Schools, Iran [PDF]
, 2014 One of the threaten behavior among managers is exhaustion. In fact, exhaustion assumed as a state of physical and emotional tiredness that appear in interaction with employees and students during working hours at school.
Mehrad, A. (Aida)
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Enfances, Familles, Générations, 2023 Research Framework: With a focus on the parental role, parenting support measures have become a lever for public policies aimed at preventing and combating inequality. Seen as a resource for explaining the school’s expectations to parents, these measures
Xavier Conus
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source