Results 121 to 130 of about 781,987 (294)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Historia (Santiago), 2010 El artículo tiene como objetivo comprender el proceso de expansión del sistema de instrucción primaria estatal, durante su período de formalización y consolidación territorial.
Macarena Ponce de León Atria
doaj
Chinese ethnic minorities and learner identity in non-autonomous schools: a systematic review
Frontiers in EducationThis systematic review investigates existing research on how ethnic minority students in China construct their identities within the “Inland Ban (Inland Class)1” at various educational levels.
Leyao Yang, Yan Liu, Zhixian Zhuang
doaj +1 more source
Estimating the Economic Return to Schooling on the Basis of Panel Data [PDF]
This paper is concerned with estimating the economic return to schooling of men in the Netherlands.We adopt an IV approach to estimate a panel data model with random individual effects.We exploit the fact that older individuals have relatively less ...
Kalwij, A.S.
core +1 more source
, 2015 sponsorship: Policy Research Centre on Study and School Careers (steunpunt SSL) financed by the Ministry of the Flemish Government (Belgium). The conclusions of the article do not necessarily reflect the views of (and do not commit) the financing body.
Poesen-Vandeputte, Mayke, Nicaise, Ides
openaire +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
New methods for comparing literacy across populations: insights from the measurement of poverty [PDF]
This paper exploits an unusual policy reform that had the effect of reducing the direct cost of schooling in Ireland in the late 1960s. This gave rise to an increased level of schooling but with effects that vary substantially across family background ...
Kevin Denny
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source