In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Medical humanities in medical schools in India
Pathiyil Ravi Shankar
doaj +1 more source
The Medical Student Performance Evaluation in global medical education: addressing a missing Middle Eastern perspective. [PDF]
Jabri A +6 more
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Developing health research capacity and capability in underserved geographies: a case study from a new medical school. [PDF]
Johnson JA, Winnett G, Ahluwalia S.
europepmc +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Evangelization and the Catholic Identity of Medical Schools [PDF]
Pellegrino, Edmund D.
core +1 more source
Affirmative action, financial support, and medical residency outcomes in Brazil: evidence from a national linked cohort study, 2018-2024. [PDF]
Mosquera PS +4 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Dental students' perceptions of preclinical and clinical skills training: a comparison between tuition-free and tuition-based schools. [PDF]
Maleki S +3 more
europepmc +1 more source

