Results 61 to 70 of about 291,016 (240)

Erectile dysfunction and associated factors among patients with diabetes in Public hospitals of Harari region, Eastern Ethiopia: modified poisson regression model

BMC Endocrine Disorders
Background Erectile dysfunction is a common problem among patients with diabetes, often going undiagnosed and having a significant negative impact on their health. This condition necessitates accurate evaluation and early intervention.
Abebe Seyoum, Aboma Motuma, Behailu Hawulte, Tamirat Getachew, Adera Debella, Addis Eyeberu   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Keeping Dr. Charles Richard Drew’s legacy alive

Journal of the Medical Library Association, 2019
The Charles R. Drew University of Medicine and Science (CDU) recently celebrated its fiftieth anniversary. The university was established to honor Dr. Charles Richard Drew, a pioneer in blood banking. As a tribute to the legacy of CDU and Dr.
Darlene Parker-Kelly, Charles P. Hobbs
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Sensitivity of RSV detection by PCR in respiratory samples is not reduced by a 24 h delay from sampling to testing with storage at room temperature

Molecular Medicine
Respiratory Syncytial Virus (RSV) is a common cause of severe respiratory tract disease in infants, the elderly and immunocompromised patients. However, there is uncertainty as to how sample handling practices affect performance of tests to detect RSV ...
Katie Lihou, Serena McGuinness, Begonia Morales-Aza, Elizabeth Begier, Kaltun Duale, Rosa Aldridge, Nellie Farhoudi, Jonathan Vowles, Dylan Thomas, Jo Southern, Jennifer Oliver, Maria Lahuerta, Kathy Schneider, Bradford D. Gessner, Adam Finn, Leon Danon, Catherine Hyams, The AvonCAP Research Group   +17 more
doaj   +1 more source

The UK medical education database (UKMED) what is it? Why and how might you use it?

BMC Medical Education, 2018
Background Educating doctors is expensive and poor performance by future graduates can literally cost lives. Whilst the practice of medicine is highly evidence based, medical education is much less so.
Jon Dowell, Jennifer Cleland, Siobhan Fitzpatrick, Chris McManus, Sandra Nicholson, Thomas Oppé, Katie Petty-Saphon, Olga Sierocinska King, Daniel Smith, Steve Thornton, Kirsty White   +10 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Ensinar cirurgia: como e para quem?

Revista do Colégio Brasileiro de Cirurgiões
O autor discute a crise atual de formação de médicos e de cirurgiões fazendo uma revisão de dados de literatura atual, referentes ao quantitativo de médicos e discussão de referências éticas e filosóficas da profissão.
Lisieux Eyer de Jesus
doaj   +1 more source