Results 41 to 50 of about 8,506,716 (400)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response

open access: yesCell Death and Disease, 2023
TP73 is expressed as multiple N- and C-terminal isoforms through two separate promoters or alternative splicing. While N-terminal p73 isoforms have been well studied, very little is known about p73 C-terminal isoforms.
Jin Zhang   +7 more
doaj   +1 more source

Categorical Inequality: Schools As Sorting Machines.

open access: yesThe Annual review of sociology, 2017
Despite their egalitarian ethos, schools are social sorting machines, creating categories that serve as the foundation of later life inequalities. In this review, we apply the theory of categorical inequality to education, focusing particularly on ...
T. Domina   +2 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Transplanted hNT Cells (“LBS Neurons”) in a Rat Model of Huntington's Disease: Good Survival, Incomplete Differentiation, and Limited Functional Recovery

open access: yesCell Transplantation, 2004
A variety of immortalized cell lines have been proposed to exhibit sufficient phenotypic plasticity to allow them to replace primary embryonic neurons for restorative cell transplantation.
Rosemary A. Fricker-Gates   +2 more
doaj   +1 more source

From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion

open access: yesViruses, 2021
Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine.
John F. Atkins   +3 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

open access: yesFEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan   +10 more
wiley   +1 more source

Novel indium(III) acetate phthalocyanine: synthesis and spectroscopic properties

open access: yesMANAS: Journal of Engineering, 2022
A new phthalocyanine 1 was synthesized, containing 2-aminophenoxy groups as tetra from its peripheral positions and indium(III) acetate in its cavity. The structure of 1 was illuminated by elemental analysis, FTIR, UV-vis and fluorescence spectroscopy ...
Fatih Mutlu   +5 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

open access: yesFEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Roadmap for UN 2030 Education Agenda for Learners with Special Educational Needs of Department of Education, Pangasinan Division II, Philippines

open access: yesJournal of ICSAR, 2018
The UN 2030 Education Agenda is a global platform directed towards creating opportunities for learners with special educational needs (LSENs) for their holistic development and eventual mainstreaming in the society.
Donato Balderas   +2 more
doaj   +1 more source

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