Results 121 to 130 of about 91,891 (247)

Analytical and Numerical Soliton Solutions of the Shynaray II‐A Equation Using the G′G,1G$$ \left(\frac{G^{\prime }}{G},\frac{1}{G}\right) $$‐Expansion Method and Regularization‐Based Neural Networks

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT Nonlinear differential equations play a fundamental role in modeling complex physical phenomena across solid‐state physics, hydrodynamics, plasma physics, nonlinear optics, and biological systems. This study focuses on the Shynaray II‐A equation, a relatively less‐explored parametric nonlinear partial differential equation that describes ...
Aamir Farooq, H. W. A. Riaz, Sadique Rehman, M. Mamun Miah, Wen Xiu Ma   +4 more
wiley   +1 more source

Matsumura‐Type Estimates and Global Solutions of a Fractional Wave Equation With Nonlocal Nonlinearity

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT The main results of this paper are the global existence and long time behavior of solutions of a fractional wave equation with a nonlocal nonlinearity. The techniques in this work rely on norm estimates of the solutions of εutt+ut+(−Δ)βu=0,u(0,x)=φ(x),ut(0,x)=ψ(x),$$ \varepsilon {u}_{tt}+{u}_t+{\left(-\Delta \right)}^{\beta }u=0,\kern1em u ...
Ibrahim Ahmad Suleman, Mokhtar Kirane
wiley   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Current Insight into Human Ornithine Aminotransferase: A Review

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani, Carla Borri Voltattorni, Riccardo Montioli   +2 more
wiley   +1 more source

x‐Ray Structure of Streptomyces avermitilis Phospholipase D Reveals a Ca2+‐Stabilized Expanded Active‐Site Cleft Adapted for Phospholipid Binding

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Phospholipase D (PLD) catalyzes the hydrolysis of phospholipids to generate phosphatidic acid and free head groups such as choline. Among bacterial PLD enzymes, Streptomyces chromofuscus PLD (SchPLD), a member of the alkaline phosphatase D (PhoD) superfamily, exhibits unique Ca2+‐dependent phospholipase activity.
Yoshiaki Yasutake, Tatsuya Hirata, Shunsuke Nomura, Kenji Konishi, Kazunari Yoneda, Shin‐ichi Sakasegawa, Haruhiko Sakuraba   +6 more
wiley   +1 more source

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

Smart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding, Zongying Li, Zaiwei Xiao, Siting Zhang, Zimai Liu, Xiaoguang Shao, Zhong Li, Wen Fu, Xusheng Shao   +8 more
wiley   +1 more source

SOME METHODS OF THE DECISION OF PROBLEMS OF NUCLEAR PHYSICS ON THE CONNECTED CONDITIONS

Вестник. Серия физическая, 2008
Some not standard methods for numerical decided of the Schrodinger equation or system of the Schrodinger equation with tensor force in nuclear physics tasks at low energies and nuclear astrophysics was consider.
S.B. Dubovichenko
doaj  

Structural insights into urocanate reductase using room‐temperature X‐ray crystallography

Acta Crystallographica Section D, EarlyView.
The active‐site dynamics of the microbial enzyme urocanate reductase were revealed by room‐temperature X‐ray crystallography.Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate‐bound versus product‐bound states.
Swati Aggarwal, Nitisha Gurav, Esko Oksanen, Karin Lindkvist-Petersson, Raminta Venskutonytė   +4 more
wiley   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, EarlyView.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source