A fast and adaptable method for high accuracy integration of the time-dependent Schrödinger equation. [PDF]
Sci Rep, 2019 Wells D, Quiney H.
europepmc +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
Rogue periodic waves of the focusing nonlinear Schrödinger equation. [PDF]
Proc Math Phys Eng Sci, 2018 Chen J, Pelinovsky DE.
europepmc +1 more source
The Geometry of Color in the Light of a Non‐Riemannian Space
Computer Graphics Forum, EarlyView.Abstract We formalize Schrödinger's definitions of hue, saturation, and lightness, building on the foundational idea from Helmholtz that these perceptual attributes can be derived solely from the perceptual metric. We identify three shortcomings in Schrödinger's approach and propose solutions to them.
Roxana Bujack +4 more
wiley +1 more source
Beam propagation management in a fractional Schrödinger equation. [PDF]
Sci Rep, 2017 Huang C, Dong L.
europepmc +1 more source
Rare dysfunctional SCN2A variants are associated with malformation of cortical development
Epilepsia, Volume 66, Issue 3, Page 914-928, March 2025.Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic variants in SCN2A are associated with a spectrum of neurodevelopmental disorders.
Jérôme Clatot +19 more
wiley +1 more source
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains
The FEBS Journal, EarlyView.Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley +1 more source
The FEBS Journal, EarlyView.Molybdenum‐dependent formate dehydrogenases (Mo‐FDHs) contain a strictly conserved lysine residue (K44) in the vicinity of an electron‐transferring [4Fe‐4S] cluster and a catalytically active molybdenum atom coordinated by two molybdopterins (MPT‐1 and MPT‐2).
Feilong Li, Michael Lienemann
wiley +1 more source
Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors
The FEBS Journal, EarlyView.Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic strategies essential. This study focuses on the role of histone deacetylases (HDACs) in liver fibrosis, particularly HDAC6.
Maria Teresa Borrello +25 more
wiley +1 more source
First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus
The FEBS Journal, EarlyView.The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi +15 more
wiley +1 more source