Results 211 to 220 of about 91,891 (247)
Extraction of new solitary wave solutions in a generalized nonlinear Schrödinger equation comprising weak nonlocality. [PDF]
Vivas-Cortez M +4 more
europepmc +1 more source
Family‐level specialization in protein domain insertion architectures
Abstract Domain insertion creates architectures where one domain interrupts another's sequence. Analysis across 2.7 million classified domains reveals that insertions occur in 20% of multidomain proteins, with 331 families exhibiting consistent architectural roles: 162 function exclusively as hosts, while 169 exclusively serve as inserted modules, such
R. Dustin Schaeffer +4 more
wiley +1 more source
Global well-posedness of the 2D nonlinear Schrödinger equation with multiplicative spatial white noise on the full space. [PDF]
Debussche A +3 more
europepmc +1 more source
Influence of Peptide‐Based Chelator Sequences on HER2‐Targeting Radiopeptide
Peptide‐based chelator consisting of Cys‐Gly‐Gly‐Gly incorporated into HER2‐targeting rL‐A9 peptide for 99mTc‐labeling. [99mTc]Tc‐CGGG‐rL‐A9 exhibited high binding affinity and tumor uptake and retention. ABSTRACT In our pursuit of developing HER2‐targeting radiolabeled peptides for detection and therapy of HER2‐positive breast cancer, the previously ...
Sonal Gupta +5 more
wiley +1 more source
An efficient computational scheme for solving coupled time-fractional Schrödinger equation via cubic B-spline functions. [PDF]
Mubashir Hayat A +5 more
europepmc +1 more source
High‐level ab initio and density functional theory calculations reveal a structural and spectroscopic transition from pla nar Cu6 to three‐dimensional Pd6, whose lowest energy triplet state undergoes a Jahn‐Teller distortion. This evolution from molecule‐like to metal‐like bonding produces distinct infrared and Raman fingerprints, providing reliable ...
Katarzyna M. Krupka +2 more
wiley +1 more source
Flavodiiron proteins (FDPs) are di‐iron enzymes that reduce NO and/or O2 with distinct substrate selectivity. We have produced E. coli FDP variants targeting second coordination‐sphere residues and determined their structures. Although the kinetics remained unchanged, the E.
Patrícia T. Borges +8 more
wiley +1 more source
Alphafuser: a parsimonious approach to predicting higher‐order protein complexes
Alphafuser is a structure‐prediction pipeline that integrates experimental interaction data with AlphaFold‐based modeling to systematically assemble multiprotein complexes in a computationally efficient manner. By implementing an ipTM‐based pruning algorithm and validating against known structures and experimental assays, Alphafuser enables the ...
Audrey Guillotin +5 more
wiley +1 more source
ABSTRACT Spiders are renowned for their ecological versatility and silk‐based innovations in materials science, yet marine environments remain virtually uncolonized by this predominantly terrestrial lineage. A striking exception is the obligate intertidal spider genus Desis, whose members have evolved extraordinary physiological and behavioural ...
Fan Li +11 more
wiley +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source

