Results 191 to 200 of about 36,400 (267)

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

open access: yesThe FEBS Journal, EarlyView.
Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet   +6 more
wiley   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

open access: yesInsect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

open access: yesJournal of Integrative Plant Biology, EarlyView.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan   +11 more
wiley   +1 more source

Barley HvBODYGUARD1 controls cuticular specialisations regulated by SHINE transcription factors

open access: yesNew Phytologist, EarlyView.
Cuticle defects result from defective HvBDG1 alleles. Summary Land plants secrete a protective outer cuticular layer with diverse functions. Barley (Hordeum vulgare L.) develops two cuticular specialisations: the β‐diketone rich wax bloom on vegetative tissues and an adherent grain surface which sticks to the hulls, leading to barley's distinctive ...
Trisha McAllister   +19 more
wiley   +1 more source

On the Naturalistic Grounds of Grounding

open access: yesRatio, EarlyView.
ABSTRACT This paper examines whether grounding can be naturalized. We adopt a tripartite framework—Ocat (scientific catalogue of existents), Otyp (ontological types), and metaphysics (natures/modal profiles)—and show that classifying as such the relata of putative grounding claims forces a dilemma.
Raoni Arroyo, Jonas R. Becker Arenhart
wiley   +1 more source

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