Results 231 to 240 of about 25,004 (307)

Chemical‐Assembled Macrophage‐Engaging Glypican‐3 × Signal Regulatory Protein‐α (SIRP‐α) Bispecific Antibody for Immunotherapy Against Liver Cancer

open access: yesMedComm, Volume 7, Issue 7, July 2026.
We developed a novel chemical strategy to generate a glypican‐3 × SIRP‐α bispecific antibody that simultaneously blocks the CD47 “don't eat me” signal, engages macrophages to target liver cancer cells for enhanced phagocytosis, and antigen presentation. This novel combination of targets demonstrates remarkable efficacy in vitro and in vivo.
Bo Tang   +14 more
wiley   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

open access: yesMedicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano   +4 more
wiley   +1 more source

How Long Is the Coast of Quantum Chemistry? Or, How to Evaluate Density Functional Theory as a Scientific Revolution

open access: yesNatural Sciences, Volume 6, Issue 3, July 2026.
Within quantum chemistry, density functional theory (DFT) is a revolution. This serves as an example of a multitude of other scientific events, supporting the idea that revolutions are always large, if observed with the appropriate magnification. ABSTRACT Distinguishing scientific revolutions from normal science is a subjective, conflicting matter ...
Sebastian Kozuch
wiley   +1 more source

The Revo‐Evo Debate in the History and Philosophy of Science

open access: yesNatural Sciences, Volume 6, Issue 3, July 2026.
The paper juxtaposes revolutionary and evolutionary positions in epistemology in general as well as the history of science. While it deems the evolutionary arguments more persuasive, it also stresses the dependence of our assessment of change on the language we choose to describe the theories and positions under consideration.
Yemima Ben‐Menahem
wiley   +1 more source

A Dialogue on Revolutions and Revolutionaries in Science: A Perspective From Quantum Mechanics

open access: yesNatural Sciences, Volume 6, Issue 3, July 2026.
ABSTRACT We discuss the notions of scientific revolutions and revolutionaries in the context of the Relativity Revolution and of the First, Second, and Third Quantum Revolutions. We conclude that at the core of the question of what qualifies as a revolution and revolutionary is an assessment of the gradients of knowledge accumulation over time, both at
Ron Folman, Bretislav Friedrich
wiley   +1 more source

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