Results 211 to 220 of about 19,010 (265)

Topliss‐Guided Optimization of Acetanilide‐Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency‐Enhancing Motif

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz   +17 more
wiley   +1 more source

Defect‐Guided Assembly of Aperiodic and Flexible Metal–Organic Frameworks From Pre‐Formed Cages

open access: yesAngewandte Chemie, Volume 138, Issue 35, 24 August 2026.
A cage‐directed strategy is used to program topologically correlated defects and induce aperiodicity in HKUST‐1‐type MOFs. A missing carboxylate group in the linker drives the formation of Cu‐vacancy domains, while Rh(II) cages spatially confine these defects.
Francisco Sánchez‐Férez   +12 more
wiley   +2 more sources

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández   +6 more
wiley   +1 more source

Quantum Plasmonic Dynamics Modeled via a Modified Langevin Noise Formalism: Numerical Studies of Single‐Photon Emission and Two‐Photon Interference

open access: yesNanophotonics, Volume 15, Issue 16, 26 August 2026.
Based on the modified Langevin noise formalism and BA‐MA theory, optimized computational formulations are demonstrated for quantum plasmonic simulations without explicit BA–MA mode construction. Plasmonic Hong‐Ou‐Mandel interference, g2, atomic population, and single‐photon probability amplitudes are efficiently analyzed, revealing directional single ...
Jisang Seo   +5 more
wiley   +1 more source

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