Results 111 to 120 of about 106,917 (289)

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

Silencing of the Charcot–Marie–Tooth associated MTMR2 gene decreases proliferation and enhances cell death in primary cultures of Schwann cells

Neurobiology of Disease, 2007
Loss of function of the myotubularin (MTM)-related protein 2 (MTMR2) in Schwann cells causes Charcot–Marie–Tooth disease type 4B1, a severe demyelinating neuropathy, but the consequences of MTMR2 disruption in Schwann cells are unknown.
Alexandre Chojnowski, Nicole Ravisé, Corinne Bachelin, Christel Depienne, Merle Ruberg, Bernard Brugg, Jocelyn Laporte, Anne Baron-Van Evercooren, Eric LeGuern   +8 more
doaj   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury

Molecular Brain, 2019
Schwann cells experience de-differentiation, proliferation, migration, re-differentiation and myelination, and participate in the repair and regeneration of injured peripheral nerves.
Hongkui Wang, Ping Zhang, Jun Yu, Fuchao Zhang, Wenzhao Dai, Sheng Yi   +5 more
doaj   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Chemical Conversion of Human Fibroblasts into Functional Schwann Cells

Stem Cell Reports, 2014
Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across germ-layer borders often requires ectopic gene expression with unpredictable side effects.
Eva C. Thoma, Claudia Merkl, Tobias Heckel, Rachel Haab, Frederic Knoflach, Corinne Nowaczyk, Nicholas Flint, Ravi Jagasia, Sannah Jensen Zoffmann, Hoa Hue Truong, Pascal Petitjean, Sebastian Jessberger, Martin Graf, Roberto Iacone   +13 more
doaj   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Upregulation of chondroitin 6-sulphotransferase-1 facilities Schwann cell migration during axonal growth [PDF]

, 2006
Cell migration is central to development and posttraumatic regeneration. The differential increase in 6-sulphated chondroitins during axonal growth in both crushed sciatic nerves and brain development suggests that chondroitin 6-sulphotransferase-1 (C6ST-
Chan, YS, Chau, CH, Jang, BR, Li, X, Liu, H, Liu, J, Shum, DKY   +6 more
core   +1 more source