Results 1 to 10 of about 5,296,721 (231)

A practical CD90.2-based FACS strategy for obtaining Schwann cell-enriched cultures from adult mouse nerves [PDF]

Frontiers in Cellular Neuroscience
Primary Schwann cell cultures derived from adult murine peripheral nerves are frequently compromised by fibroblast overgrowth, limiting their utility for in vitro studies.
Karen Libberecht, Karen Libberecht, Karen Libberecht, Hanne Jeurissen, Nathalie Dirkx, Yara Lambrechts, Yara Lambrechts, Yara Lambrechts, Lise Van Horebeek, Koen Kuipers, Femke Reubens, Jana Van Broeckhoven, Tim Vangansewinkel, Tim Vangansewinkel, Tim Vangansewinkel, Tim Vangansewinkel, Esther Wolfs   +16 more
doaj   +2 more sources

Macrophages Regulate Schwann Cell Maturation after Nerve Injury

Cell Reports, 2018
Summary: Pro-regenerative macrophages are well known for their role in promoting tissue repair; however, their specific roles in promoting regeneration of the injured nerve are not well defined.
Jo Anne Stratton, Alexandra Holmes, Nicole L. Rosin, Sarthak Sinha, Mohit Vohra, Nicole E. Burma, Tuan Trang, Rajiv Midha, Jeff Biernaskie   +8 more
doaj   +3 more sources

Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling [PDF]

JCI Insight
In this study, we used single-cell RNA sequencing to delineate the contributions of muscle-resident Schwann cells to neuromuscular junction (NMJ) remodeling by comparing a model of stable innervation with models of reinnervation following partial or ...
Steve D. Guzman, Ahmad Abu-Mahfouz, Carol S. Davis, Lloyd P. Ruiz, Peter C.D. Macpherson, Susan V. Brooks   +5 more
doaj   +2 more sources

The Effect of Schwann Cells/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy

Frontiers in Cellular Neuroscience, 2022
Peripheral neuropathy is a common neurological issue that leads to sensory and motor disorders. Over time, the treatment for peripheral neuropathy has primarily focused on medications for specific symptoms and surgical techniques.
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Gang Chen, Gang Chen, Zhong-Ya Wei   +8 more
doaj   +1 more source

Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential. [PDF]

PLoS ONE, 2011
Multipotent somatic stem cells have been identified in various adult tissues. However, the stem/progenitor cells of the peripheral nerves have been isolated only from fetal tissues.
Takehiko Takagi, Ken Ishii, Shinsuke Shibata, Akimasa Yasuda, Momoka Sato, Narihito Nagoshi, Harukazu Saito, Hirotaka J Okano, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura   +10 more
doaj   +1 more source

Retracing Schwann Cell Developmental Transitions in Embryonic Dissociated DRG/Schwann Cell Cocultures in Mice

Frontiers in Cellular Neuroscience, 2021
Embryonic Dissociated Dorsal Root Ganglia (DRG) cultures are often used to investigate the role of novel molecular pathways or drugs in Schwann cell development and myelination.
Venkat Krishnan Sundaram, Tatiana El Jalkh, Tatiana El Jalkh, Rasha Barakat, Rasha Barakat, Camille Julie Isabelle Fernandez, Charbel Massaad, Julien Grenier   +7 more
doaj   +1 more source

Influence of cold-stimulated adipocyte supernatant on the expression of adhesion-related molecules in Schwann cell line

Biochemistry and Biophysics Reports, 2023
Bell's palsy is the most common form of facial nerve palsy. This study aimed to explore the pathogenesis of Bell's palsy by investigating the effect of cold-stimulated adipocyte supernatant on adhesion molecule expression in Schwann cell line.
Tiefeng Zhang, Yaxin Gan, Yulan Bai, Weijiang Hao, Ziqi Zeng, Feng Wu, Xianqi Li   +6 more
doaj   +1 more source

Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats

Mediators of Inflammation, 2023
Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang, Shunyi Lu, Ya Yuan, Lei Huang, Mengxuan Bian, Jieqin Yu, Jiapeng Zou, Libo Jiang, Dehua Meng, Jian Zhang   +9 more
doaj   +1 more source

Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis

Cell Reports, 2023
Summary: Schwann cells play critical roles in peripheral neuropathies; however, the regulatory mechanisms of their homeostasis remain largely unknown. Here, we show that nucleoporin Seh1, a component of nuclear pore complex, is important for Schwann cell
Mei Wu, Man Li, Wei Liu, Minbiao Yan, Li Li, Weichao Ding, Ximing Nian, Wenxiu Dai, Di Sun, Yanqin Zhu, Qiuying Huang, Xiaoyun Lu, Zhiyu Cai, Fan Hong, Xuewen Li, Ling Zhang, Zhixiong Liu, Wei Mo, Xueqin Zhang, Liang Zhang   +19 more
doaj   +1 more source

Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration [PDF]

Jichu yixue yu linchuang, 2022
Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways
YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin, LIU Yu-pu
doaj   +1 more source