Results 21 to 30 of about 59,053 (258)
Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway
Molecules, 2021 Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the function of signaling molecules that differ depending on the context in which the molecules are engaged.
Kyuhee Park +4 more
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Mining Gene Ontology Data with AGENDA
Bioinformatics and Biology Insights, 2012 The Gene Ontology (GO) initiative is a collaborative effort that uses controlled vocabularies for annotating genetic information. We here present AGENDA ( A pplication for mining Gen e Ontology Da ta), a novel web-based tool for accessing the GO database.
Guvanch Ovezmyradov +2 more
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Schwann Cell Myelination [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Myelinated nerve fibers are essential for the rapid propagation of action potentials by saltatory conduction. They form as the result of reciprocal interactions between axons and Schwann cells. Extrinsic signals from the axon, and the extracellular matrix, drive Schwann cells to adopt a myelinating fate, whereas myelination reorganizes the axon for its
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Rab27a/Slp2-a complex is involved in Schwann cell myelination
Neural Regeneration Research, 2016 Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were emphasized.
Wen-feng Su +7 more
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Transcriptional Regulation Induced by cAMP Elevation in Mouse Schwann Cells
ASN Neuro, 2014 In peripheral nerves, Schwann cell development is regulated by a variety of signals. Some of the aspects of Schwann cell differentiation can be reproduced in vitro in response to forskolin, an adenylyl cyclase activator elevating intracellular cAMP ...
Daniela Schmid +2 more
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The Neurobiology of Schwann Cells
Brain Pathology, 1999 This selective review of Schwann cell biology focuses on questions relating to the origins, development and differentiation of Schwann cells and the signals that control these processes. The importance of neuregulins and their receptors in controlling Schwann cell precursor survival and generation of Schwann cells, and the role of these molecules in ...
R, Mirsky, K R, Jessen
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Macrophages Regulate Schwann Cell Maturation after Nerve Injury
Cell Reports, 2018 Summary: Pro-regenerative macrophages are well known for their role in promoting tissue repair; however, their specific roles in promoting regeneration of the injured nerve are not well defined.
Jo Anne Stratton +8 more
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Neural Regeneration Research, 2018 Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury (SCI) and is currently in clinical trials. In our continuing efforts to improve Schwann cell transplantation strategies, we sought to determine the combined ...
Yee-Shuan Lee +3 more
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Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats
Neural Regeneration Research, 2015 Edaravone has been shown to delay neuronal apoptosis, thereby improving nerve function and the microenvironment after spinal cord injury. Edaravone can provide a favorable environment for the treatment of spinal cord injury using Schwann cell ...
Shu-quan Zhang +6 more
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Cell Transplantation, 2013 Olfactory mucosa (OM)-derived olfactory ensheathing cells (OECs) are attractive candidates for autologous cell transplantation-based therapy of nervous system injury.
Susanne Ziege +2 more
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