Results 11 to 20 of about 5,296,721 (231)

An organized 3D in vitro model for peripheral nerve studies [PDF]

, 2013
Three-dimensional cell cultures have been proposed to address the limitations in two-dimensional cell cultures (i.e. lack of relevant architectural features) and very few have developed 3D cell culture methods for peripheral nerve studies. Therefore, the
Daud, Muhammad Fauzi
core   +6 more sources

Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. [PDF]

PLoS ONE, 2010
The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps.
Juliane Bremer, Tracy O'Connor, Cinzia Tiberi, Hubert Rehrauer, Joachim Weis, Adriano Aguzzi   +5 more
doaj   +1 more source

Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve.

PLoS ONE, 2020
Transference of RNAs and ribosomes from Schwann cell-to-axon was demonstrated in normal and regenerating peripheral nerves. Previously, we have shown that RNAs transfer is dependent on F-actin cytoskeleton and Myosin Va.
Lucía Canclini, Joaquina Farias, Andrés Di Paolo, José R Sotelo-Silveira, Gustavo Folle, Alejandra Kun, José R Sotelo   +6 more
doaj   +1 more source

Integrative study of Arabidopsis thaliana metabolomic and transcriptomic data with the interactive MarVis-Graph software [PDF]

PeerJ, 2014
State of the art high-throughput technologies allow comprehensive experimental studies of organism metabolism and induce the need for a convenient presentation of large heterogeneous datasets.
Manuel Landesfeind, Alexander Kaever, Kirstin Feussner, Corinna Thurow, Christiane Gatz, Ivo Feussner, Peter Meinicke   +6 more
doaj   +2 more sources

Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway

Molecules, 2021
Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the function of signaling molecules that differ depending on the context in which the molecules are engaged.
Kyuhee Park, Yoonkyoung Shin, Gyeongbeen Lee, Hwantae Park, Yongmun Choi   +4 more
doaj   +1 more source

Myelination, axonal loss and Schwann cell characteristics in axonal polyneuropathy compared to controls.

PLoS ONE, 2021
IntroductionPolyneuropathy is a debilitating condition characterized by distal sensory and motor deficits. Schwann cell dysfunction and axonal loss are integral factors in pathophysiology and disease progression of polyneuropathy.AimsThe aim of this ...
Eva Placheta-Györi, Lea Maria Brandstetter, Jakob Zemann-Schälss, Sonja Wolf, Christine Radtke   +4 more
doaj   +2 more sources

c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]

, 2012
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy, Turmaine, Mark, Mirsky, Rhona, Quintes, Susanne, Wicher, GK, Chabrol, Elodie, Latouche, Morwena, Chabrol, E, Behrens, A, Mirsky, R, Woodhoo, Ashwin, Jenkins, B, Mitter, Richard, Quintes, S, Turmaine, M, Greensmith, L, Woodhoo, A, Mitter, R, Behrens, Axel, Raivich, Gennadij, Wicher, Grzegorz K.,, Latouche, M, Banerjee, Annbily, Arthur-Farraj, PJ, Wilton, DK, Banerjee, A, Rahman, Mary, Jessen, KR, Rahman, M, Greensmith, Linda, Raivich, G, Arthur-Farraj, Peter J., Wilton, Daniel K., Jessen, Kristjan R.   +33 more
core   +1 more source

Betacellulin regulates peripheral nerve regeneration by affecting Schwann cell migration and axon elongation

Molecular Medicine, 2021
Background Growth factors execute essential biological functions and affect various physiological and pathological processes, including peripheral nerve repair and regeneration.
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi   +7 more
doaj   +1 more source

ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury [PDF]

, 2006
Neuregulin/erbB signaling is critically required for survival and proliferation of Schwann cells as well as for establishing correct myelin thickness of peripheral nerves during development.
Atanasoski, Suzana, Birchmeier, C., Garratt, Alistair N., Birchmeier, Carmen, Suter, U., Sirkowski, E., Scherer, Steven S., Atanasoski, S., Suter, Ueli, Scherer, S.S., Sirkowski, Erich, Garratt, A.N., S. Atanasoski, Leone, Dino, Leone, D., Atanasoski S, Birchmeier C, Suter U, Scherer SS, Garratt AN, Leone D, Sirkowski E   +21 more
core   +1 more source

Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases [PDF]

, 2010
Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues.
Kiichiro Matsumura, Matsumura, Kiichiro, Masaki, Toshihiro, Toshihiro Masaki   +3 more
core   +1 more source